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Impact of the Kidney Transplantation Moratorium in France Because of the COVID-19 Pandemic: A Cohort-based Study

dc.rights.licenseopenen_US
dc.contributor.authorBONNEMAINS, Vincent
dc.contributor.authorLE BORGNE, Florent
dc.contributor.authorSAVOYE, Emile
dc.contributor.authorLEGEAI, Camille
dc.contributor.authorPASTURAL, Myriam
dc.contributor.authorBAYAT-MAKOEI, Sahar
dc.contributor.authorLENAIN, Remi
dc.contributor.authorRAGOT, Stephanie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRE, Karen
IDREF: 183599128
dc.contributor.authorCOUCHOUD, Cecile
dc.contributor.authorFOUCHER, Yohann
dc.date.accessioned2022-10-31T10:12:41Z
dc.date.available2022-10-31T10:12:41Z
dc.date.issued2022-09-30
dc.identifier.issn1534-6080 (Electronic) 0041-1337 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170168
dc.description.abstractEnBACKGROUND: The COVID-19 pandemic has resulted in worldwide kidney transplantation (KT) moratoriums. The impacts of these moratoriums on the life expectancy of KT candidates remain unclear. METHODS: We simulated the evolution of several French candidate populations for KT using a multistate semi-Markovian approach and according to moratorium durations ranging from 0 to 24 mo. The transition rates were modeled from the 63 927 French patients who began dialysis or were registered on the waiting list for KT between 2011 and 2019. RESULTS: Among the 8350 patients active on the waiting list at the time of the French KT moratorium decided on March 16, 2020, for 2.5 mo, we predicted 4.0 additional months (confidence interval [CI], 2.8-5.0) on the waiting list and 42 additional deaths (CI, -70 to 150) up to March 16, 2030, compared with the scenario without moratorium. In this population, we reported a significant impact for a 9-mo moratorium duration: 135 attributable deaths (CI, 31-257) up to March 16, 2030. Patients who became active on the list after March 2020 were less impacted; there was a significant impact for an 18-mo moratorium (175 additional deaths [CI, 21-359]) in the 10 862 prevalent end-stage renal disease patients on March 16, 2020 and for a 24-mo moratorium (189 additional deaths [CI, 10-367]) in the 16 355 incident end-stage renal disease patients after this date. CONCLUSION: The temporary moratorium of KT during a COVID-19 peak represents a sustainable decision to free up hospitals' resources if the moratorium does not exceed a prolonged period.
dc.language.isoENen_US
dc.title.enImpact of the Kidney Transplantation Moratorium in France Because of the COVID-19 Pandemic: A Cohort-based Study
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/tp.0000000000004369en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36195001en_US
bordeaux.journalTransplantationen_US
bordeaux.page2416-2425
bordeaux.volume106
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue12
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03820511
hal.version1
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Transplantation&rft.date=2022-09-30&rft.volume=106&rft.issue=12&rft.spage=2416-2425&rft.epage=2416-2425&rft.eissn=1534-6080%20(Electronic)%200041-1337%20(Linking)&rft.issn=1534-6080%20(Electronic)%200041-1337%20(Linking)&rft.au=BONNEMAINS,%20Vincent&LE%20BORGNE,%20Florent&SAVOYE,%20Emile&LEGEAI,%20Camille&PASTURAL,%20Myriam&rft.genre=article


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