Multicenter study to assess surgical treatments of 452 sinonasal intestinal-type adenocarcinomas: A REFCOR study
| dc.rights.license | open | en_US |
| dc.contributor.author | DE GABORY, Ludovic | |
| dc.contributor.author | WAUBANT, Alice | |
| dc.contributor.author | VERILLAUD, Benjamin | |
| dc.contributor.author | MICHEL, Justin | |
| dc.contributor.author | MALARD, Olivier | |
| dc.contributor.author | RUMEAU, Cecile | |
| dc.contributor.author | JANKOWSKI, Roger | |
| dc.contributor.author | MOYA-PLANA, Antoine | |
| dc.contributor.author | VERGEZ, Sebastien | |
| dc.contributor.author | FAVIER, Valentin | |
| dc.contributor.author | MORTUAIRE, Geoffrey | |
| dc.contributor.author | RIGHINI, Christian | |
| dc.contributor.author | PATRON, Vincent | |
| dc.contributor.author | THARIAT, Juliette | |
| dc.contributor.author | DUPIN, Charles | |
| dc.contributor.author | COELHO, Julien | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BENARD, Antoine | |
| dc.date.accessioned | 2022-10-26T09:23:57Z | |
| dc.date.available | 2022-10-26T09:23:57Z | |
| dc.date.issued | 2022-08-13 | |
| dc.identifier.issn | 1532-2157 (Electronic) 0748-7983 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170114 | |
| dc.description.abstractEn | PURPOSE: The objective was to assess the local oncological outcomes of endoscopic versus external surgical treatment of sinonasal intestinal-type adenocarcinomas (ITAC) and the factors of recurrence. METHODS: a retrospective non-randomized case-control multicenter study was carried out, including 452 untreated sinonasal ITACs recruited from 10 tertiary referral centers. The tumors were re-classified according to the UICC 2017 (pT). Survival curves were obtained using the Kaplan-Meier method. Univariate analysis was done with the log-rank test. Multivariate analysis was performed with a Cox model adjusted for age, T stage, and radiotherapy. A binary logistic regression compared surgical complications and performed two supplementary analyses on positive margins. RESULTS: We compared 195 and 257 patients operated by the external and endoscopic approach, respectively. The mean follow-up was 59.2 ± 48.7 months. Post-operative margins were invaded in 30.6 versus 18.9% of patients, respectively (p = 0.007). The overall recurrence rate was 33.8 versus 24.6%, respectively (p = 0.034). There was a significant difference in favor of the endoscopic approach regarding local recurrence-free survival thanks to better surgical margins in univariate and multivariate analysis (Odd Ratio = 2.01 (1.2-3.36) p = 0.0087). The complication rate (Odds Ratio = 3.4 (1.79-6.32) p < 0.001) was significantly lower in the endoscopic group. The histological positivity of signet-ring cells shows a statistically significant difference in recurrence-free survival (p = 0.0028). CONCLUSION: the oncological control of ITAC is better through the endoscopic approach, with negative margins and the absence of signet-ring-cells, two independent factors of recurrence. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Adenocarcinoma | |
| dc.subject.en | Sinus cancer | |
| dc.subject.en | Nasal cancer | |
| dc.subject.en | Endoscopic sinus surgery | |
| dc.subject.en | Wood dust | |
| dc.subject.en | REFCOR | |
| dc.title.en | Multicenter study to assess surgical treatments of 452 sinonasal intestinal-type adenocarcinomas: A REFCOR study | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.ejso.2022.07.021 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35995650 | en_US |
| bordeaux.journal | EJSO - European Journal of Surgical Oncology | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | PHARES_BPH | en_US |
| bordeaux.team | USMR | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03830315 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-10-26T09:24:10Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=EJSO%20-%20European%20Journal%20of%20Surgical%20Oncology&rft.date=2022-08-13&rft.eissn=1532-2157%20(Electronic)%200748-7983%20(Linking)&rft.issn=1532-2157%20(Electronic)%200748-7983%20(Linking)&rft.au=DE%20GABORY,%20Ludovic&WAUBANT,%20Alice&VERILLAUD,%20Benjamin&MICHEL,%20Justin&MALARD,%20Olivier&rft.genre=article |
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