Burden of hepatocellular cancer in patients with type-2 diabetes mellitus: a 2011-2020, french, longitudinal, retrospective, national, cohort study
| dc.rights.license | open | en_US |
| dc.contributor.author | PARLATI, Lucia | |
| dc.contributor.author | BOUAM, Samir | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SCHWARZINGER, Michael | |
| dc.contributor.author | TSOCHATZIS, Emmanuel | |
| dc.contributor.author | SOGNI, Philippe | |
| dc.contributor.author | POL, Stanislas | |
| dc.contributor.author | MALLET, Vincent | |
| dc.date.accessioned | 2022-10-18T14:09:06Z | |
| dc.date.available | 2022-10-18T14:09:06Z | |
| dc.date.issued | 2022-07 | |
| dc.identifier.issn | 0168-8278 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170066 | |
| dc.description.abstractEn | Background and aims: There are uncertainties on the burden of hepatocellular cancer (HCC) in patients with type-2 diabetes (T2D) in France. We therefore measured national incidences and risks of inhospital HCC. Method: The data source was the 2011–2020 National Hospital Discharge database.We selected all T2D patients. HCC and competing death incidences were measured overall and without well-identified risk factors of liver disease progression, including alcoholic liver disease. Risks were computed with multinomial logistic regression models. Results: The sample comprised 2, 883, 684 adults. Mean (IQR) age was 67 (58, 77) years and 54% were men. HCC incidence (95% CI) was 1.19 (1.17–1.21) per 1000 person-years at risk, totaling 26, 136 (0.9%) cases over 12, 504, 690 patient-years. A history of alcohol use disorders and non-metabolic liver-related risk factors were recorded among 55% and 21% of incident cases, respectively. In patients without well-identified risk factors of liver disease progression, HCC incidence was 0.57 (0.55–0.58) per 1000 person-years at risk. Male sex, age in the 40–70 years category, alcohol use disorders [aOR 20.8 (20.0–21.5)], and obesity [aOR 1.24 (1.2–1.28)] were independently associated with a higher risk of HCC than of competing mortality. Conclusion: A history of alcohol use disorders was the main driver of liver disease progression to HCC in French patients with T2D. Obesity increased the risk of HCC by ∼25%. Patients with T2D should be advised to abstain from alcohol. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Burden of hepatocellular cancer in patients with type-2 diabetes mellitus: a 2011-2020, french, longitudinal, retrospective, national, cohort study | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1016/S0168-8278(22)00493-7 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| bordeaux.journal | Journal of Hepatology | en_US |
| bordeaux.page | S41-S42 | en_US |
| bordeaux.volume | 77 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | Supplement 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | PHARES_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03819876 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-10-18T14:09:08Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Hepatology&rft.date=2022-07&rft.volume=77&rft.issue=Supplement%201&rft.spage=S41-S42&rft.epage=S41-S42&rft.eissn=0168-8278&rft.issn=0168-8278&rft.au=PARLATI,%20Lucia&BOUAM,%20Samir&SCHWARZINGER,%20Michael&TSOCHATZIS,%20Emmanuel&SOGNI,%20Philippe&rft.genre=article |
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