Maternal pre-pregnancy BMI and offspring hyperactivity-inattention trajectories from 3 to 8 years in the EDEN birth cohort study
| dc.rights.license | open | en_US |
| dc.contributor.author | DOW, Courtney | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GALERA, Cedric
ORCID: 0000-0003-0549-9608 IDREF: 110034007 | |
| dc.contributor.author | CHARLES, Marie-Aline | |
| dc.contributor.author | HEUDE, Barbara | |
| dc.date.accessioned | 2022-10-17T12:15:23Z | |
| dc.date.available | 2022-10-17T12:15:23Z | |
| dc.date.issued | 2022-07-19 | |
| dc.identifier.issn | 1435-165X (Electronic) 1018-8827 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170037 | |
| dc.description.abstractEn | Evidence suggests obesity during pregnancy is associated with offspring attention-deficit hyperactivity disorder. However, studies have been limited to evaluating the association at a single age with inadequate data on important maternal lifestyle confounders and unmeasured familial confounding. The objective of this study was to examine the association between maternal pre-pregnancy body mass index (BMI) and child hyperactivity-inattention symptoms (HIS) at 3, 5 and 8 years. Data came from the EDEN mother-child cohort. Maternal pre-pregnancy BMI status (kg/m(2)) was calculated using pre-pregnancy weight and height (self-reported by mothers or measured by midwives). HIS were assessed by parental-report on the Strengths and Difficulties Questionnaire at 3, 5 and 8 years of age and used to derive developmental trajectories of HIS (n = 1428). Multivariate models were adjusted for confounders including socioeconomic status, maternal lifestyle behaviours (exercise, diet, smoking, alcohol), childcare and a stimulating home environment. Paternal BMI was used as a negative control. Compared to a normal pre-pregnancy BMI, pre-pregnancy maternal obesity was positively associated with increased odds of a high HIS trajectory between 3 and 8 years old in both unadjusted and adjusted logistic regression (adjusted odds ratio [aOR] 1.87 [95% CI 1.12, 3.12]). Pre-pregnancy overweight was not significantly associated after adjustment for confounders (aOR 1.32 [0.87, 2.01]). Maternal pre-pregnancy obesity, but not overweight, was associated with increased likelihood of a high HIS trajectory in children from 3 to 8 years old. This association persisted despite controlling for many important maternal lifestyle factors and paternal BMI. Further research is warranted to identify possible mediators involved. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Hyperactivity | |
| dc.subject.en | Attention-deficit disorder | |
| dc.subject.en | Attention | |
| dc.subject.en | Hyperactivity | |
| dc.subject.en | Obesity | |
| dc.subject.en | Body mass index | |
| dc.title.en | Maternal pre-pregnancy BMI and offspring hyperactivity-inattention trajectories from 3 to 8 years in the EDEN birth cohort study | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s00787-022-02047-x | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35851811 | en_US |
| bordeaux.journal | European Child and Adolescent Psychiatry | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | HEALTHY_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| hal.identifier | hal-03817719 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-10-17T12:15:26Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Child%20and%20Adolescent%20Psychiatry&rft.date=2022-07-19&rft.eissn=1435-165X%20(Electronic)%201018-8827%20(Linking)&rft.issn=1435-165X%20(Electronic)%201018-8827%20(Linking)&rft.au=DOW,%20Courtney&GALERA,%20Cedric&CHARLES,%20Marie-Aline&HEUDE,%20Barbara&rft.genre=article |
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