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Prodromal characteristics of dementia with Lewy bodies: baseline results of the MEMENTO memory clinics nationwide cohort

dc.rights.licenseopenen_US
dc.contributor.authorBLANC, Frederic
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOUTELOUP, Vincent
dc.contributor.authorPAQUET, Claire
dc.contributor.authorCHUPIN, Marie
dc.contributor.authorPASQUIER, Florence
dc.contributor.authorGABELLE, Audrey
dc.contributor.authorCECCALDI, Mathieu
dc.contributor.authorDE SOUSA, Paulo Loureiro
dc.contributor.authorKROLAK-SALMON, Pierre
dc.contributor.authorDAVID, Renaud
dc.contributor.authorFISCHER, Clara
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529
IDREF: 058586105
dc.contributor.authorWALLON, David
dc.contributor.authorMOREAUD, Olivier
dc.contributor.authorSAUVEE, Mathilde
dc.contributor.authorBELIN, Catherine
dc.contributor.authorHARSTON, Sandrine
dc.contributor.authorBOTZUNG, Anne
dc.contributor.authorALBASSER, Timothee
dc.contributor.authorDEMUYNCK, Catherine
dc.contributor.authorNAMER, Izzie
dc.contributor.authorHABERT, Marie-Odile
dc.contributor.authorKREMER, Stephane
dc.contributor.authorBOUSIGES, Olivier
dc.contributor.authorVERNY, Marc
dc.contributor.authorMULLER, Candice
dc.contributor.authorPHILIPPI, Nathalie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHENE, Genevieve
dc.contributor.authorCRETIN, Benjamin
dc.contributor.authorMANGIN, Jean-Francois
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.date.accessioned2022-10-14T14:30:18Z
dc.date.available2022-10-14T14:30:18Z
dc.date.issued2022-07-19
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170027
dc.description.abstractEnBACKGROUND: Isolated subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) are the prodromal phases of dementia with Lewy bodies (DLB). MEMENTO is a nationwide study of patients with SCI and MCI with clinic, neuropsychology, biology, and brain imaging data. We aimed to compare SCI and MCI patients with symptoms of prodromal DLB to others in this study at baseline. METHODS: Participants of the French MEMENTO cohort study were recruited for either SCI or MCI. Among them, 892 were included in the Lewy sub-study, designed to search specifically for symptoms of DLB. Probable prodromal DLB diagnosis (pro-DLB group) was done using a two-criteria cutoff score among the four core clinical features of DLB. This Pro-DLB group was compared to two other groups at baseline: one without any core symptoms (NS group) and the one with one core symptom (1S group). A comprehensive cognitive battery, questionnaires on behavior, neurovegetative and neurosensory symptoms, brain 3D volumetric MRI, CSF, FDG PET, and amyloid PET were done. RESULTS: The pro-DLB group comprised 148 patients (16.6%). This group showed more multidomain (59.8%) MCI with slower processing speed and a higher proportion of patients with depression, anxiety, apathy, constipation, rhinorrhea, sicca syndrome, and photophobia, compared to the NS group. The pro-DLB group had isolated lower P-Tau in the CSF (not significant after adjustments for confounders) and on brain MRI widening of sulci including fronto-insular, occipital, and olfactory sulci (FDR corrected), when compared to the NS group. Evolution to dementia was not different between the three groups over a median follow-up of 2.6 years. CONCLUSIONS: Patients with symptoms of prodromal DLB are cognitively slower, with more behavioral disorders, autonomic symptoms, and photophobia. The occipital, fronto-insular, and olfactory bulb involvement on brain MRI was consistent with symptoms and known neuropathology. The next step will be to study the clinical, biological, and imaging evolution of these patients. TRIAL REGISTRATION: Clinicaltrials.gov , NCT01926249.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enDementia with Lewy bodies
dc.subject.enProdromal
dc.subject.enMild cognitive impairment
dc.subject.enSubjective cognitive impairment
dc.subject.enLewy body disease
dc.subject.enMild neurocognitive impairment
dc.title.enProdromal characteristics of dementia with Lewy bodies: baseline results of the MEMENTO memory clinics nationwide cohort
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s13195-022-01037-0en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35854388en_US
bordeaux.journalAlzheimer's Research & Therapyen_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.teamPHARES_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDCentre Hospitalier Universitaire de Bordeauxen_US
bordeaux.identifier.funderIDFondation Plan Alzheimeren_US
bordeaux.identifier.funderIDMinistère de l'Enseignement supérieur, de la Recherche et de l'Innovationen_US
hal.identifierhal-03769651
hal.version1
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20Research%20&%20Therapy&rft.date=2022-07-19&rft.volume=14&rft.issue=1&rft.au=BLANC,%20Frederic&BOUTELOUP,%20Vincent&PAQUET,%20Claire&CHUPIN,%20Marie&PASQUIER,%20Florence&rft.genre=article


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