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Proton pump inhibitors are still overprescribed for hospitalized children

dc.rights.licenseopenen_US
dc.contributor.authorARNOUX, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBAILHACHE, Marion
dc.contributor.authorTETARD, Candice
dc.contributor.authorREBOUISSOUX, Laurent
dc.contributor.authorCLOUZEAU, Haude
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLAMIREAU, Thierry
dc.contributor.authorENAUD, Raphael
dc.date.accessioned2022-10-14T12:42:21Z
dc.date.available2022-10-14T12:42:21Z
dc.date.issued2022-05
dc.identifier.issn1769-664X (Electronic) 0929-693X (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170020
dc.description.abstractEnOBJECTIVE: The use of proton pump inhibitors has increased exponentially over the past 20 years. Several side effects have been reported and concerns exist about the consequences of long-term proton pump inhibitors on health, leading to limitation of their use. The present study analyzed prescriptions of proton pump inhibitors at inpatient units and assessed their compliance with current recommendations. METHODS: This single-center, observational, retrospective study reviewed medical file of patients hospitalized at the pediatric medical departments of the Bordeaux University Hospital between April 1 and September 30, 2019. Patients younger than 18 years, hospitalized in the pediatric hospital units and treated with proton pump inhibitors were included. Prescriptions of proton pump inhibitors were compared with French and international guidelines. RESULTS: Proton pump inhibitors were prescribed for 251 of 2237 children (11%), mainly for gastroesophageal reflux disease (47%) and prevention of peptic ulcer disease (32.7%). Proton pump inhibitor prescription complied to recommendations in 34.5% of cases, less often in children aged younger than 1 year (13.5%) than in older children. Compliance to recommendations was lower when proton pump inhibitors were indicated for the prevention of peptic disease (5%) than for gastroesophageal reflux disease (48%). CONCLUSIONS: Proton pump inhibitors are frequently prescribed for hospitalized children, and indications comply with recommendations in only 35% of the cases. Efforts in spreading awareness of the recommendations on the use of proton pump inhibitors in children are mandatory among hospital pediatricians.
dc.language.isoENen_US
dc.title.enProton pump inhibitors are still overprescribed for hospitalized children
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.arcped.2022.02.004en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35304031en_US
bordeaux.journalArchives de Pédiatrieen_US
bordeaux.page258-262en_US
bordeaux.volume29en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamAHEAD_BPHen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03815227
hal.version1
hal.date.transferred2022-10-14T12:42:23Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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