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Large scale studies of the influence of GMO-based corn diet after 6 months of consumption in Wistar rats

hal.structure.identifierToxAlim [ToxAlim]
dc.contributor.authorSALLES, Bernard
hal.structure.identifierReproduction et développement des plantes [RDP]
dc.contributor.authorROGOWSKY, Peter
hal.structure.identifierUnité de recherche Mycologie et Sécurité des Aliments [MycSA]
dc.contributor.authorFORGET, Florence
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorMOING, Annick
hal.structure.identifierToxAlim [ToxAlim]
dc.contributor.authorSERVIEN, Rémi
hal.structure.identifierPrévention et promotion de la cancérogénèse par les aliments [ToxAlim-PPCA]
dc.contributor.authorPRIYMENKO, Nathalie
hal.structure.identifierMetaToul AXIOM [E20]
dc.contributor.authorCANLET, Cécile
hal.structure.identifierTranscriptomic impact of Xenobiotics [E23 TRiX]
dc.contributor.authorLIPPI, Yannick
hal.structure.identifierMethodomics
dc.contributor.authorLE GALL, Caroline
hal.structure.identifierU 699
dc.contributor.authorBERTHELOT, Laureline
hal.structure.identifierProfilomic [Boulogne-Billancourt]
dc.contributor.authorCORMAN, Bruno
hal.structure.identifierGroupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes [GERHM]
hal.structure.identifierÉcole des Hautes Études en Santé Publique [EHESP] [EHESP]
hal.structure.identifierInstitut de recherche en santé, environnement et travail [Irset]
dc.contributor.authorJEGOU, Bernard
hal.structure.identifierToxAlim [ToxAlim]
dc.contributor.authorCRAVEDI, Jean Pierre
hal.structure.identifierLaboratoire d'étude des Résidus et Contaminants dans les Aliments [LABERCA]
dc.contributor.authorANTIGNAC, Jean-Philippe
hal.structure.identifierToxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124]
hal.structure.identifierUniversité Paris Descartes - Paris 5 [UPD5]
dc.contributor.authorBAROUKI, Robert
hal.structure.identifierToxAlim [ToxAlim]
dc.contributor.authorARNICH, Nathalie
hal.structure.identifierToxAlim [ToxAlim]
dc.contributor.authorDANDERE-ABDOULKARIM, Kadidiatou
hal.structure.identifierToxAlim [ToxAlim]
dc.contributor.authorFERRIER, Laurent
hal.structure.identifierToxAlim [ToxAlim]
dc.contributor.authorBROUX, Bérengère
hal.structure.identifierToxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124]
hal.structure.identifierUniversité Paris Descartes - Paris 5 [UPD5]
dc.contributor.authorCOUMOUL, Xavier
dc.date.issued2017
dc.date.conference2017-09-10
dc.description.abstractEnWistar rats were fed during 6 months with 33% maize, either non genetically modified or containing MON810 or NK603 (11% and 33%). Extensive chemical analysis by MS and NMR profiling and targeted analyses were undertaken to qualify the harvests and quantify in maize and pellets macro- and micronutrients, anti-nutrients and undesirable substances and contaminants. All diets contained low levels (50 to 100 fold lower than the MRL values) of undesirable substances. Thirty rats per gender were fed with 8 different diets: MON810 (11% and 33%) plus isogenic control, NK603 (11% and 33% ± glyphosate treatment) and isogenic control. Rats were sacrificed after 3 months (sub-group A, 10 rats per diet, per gender) and 6 months (sub-group B, 12 rats and C, 8 rats per diet, per gender). Urine were collected in metabolic cages and blood at 90 (sub-group A), 90/135/180 (sub-group B) and 180 days of feeding (sub-group C). In addition to classical toxicological analysis we performed metabolomics and hormones quantification in blood and urine, transcriptomics on liver and kidney, gut barrier analysis, kidney and gonads targeted immunohistology. Statistical analyses were conducted first blindly and thereafter on the basis of relevant pair-wise comparison. We easily discriminate the rat gender or maize origin. Among the numerous statistically significant differences in pair-wise comparisons some concerned GMO and non-GMO, but no biological relevance could be established due to the lack of differences in biologically linked variables, dose-response effects or clinical disorders.
dc.language.isoen
dc.source.titleToxicology Letters
dc.title.enLarge scale studies of the influence of GMO-based corn diet after 6 months of consumption in Wistar rats
dc.typeCommunication dans un congrès
dc.identifier.doi10.1016/j.toxlet.2017.07.297
dc.subject.halSciences du Vivant [q-bio]
bordeaux.pagenp
bordeaux.volume280, Supplement 1, Special Issue SI
bordeaux.conference.title53. Congress of the European Societies of Toxicology (EUROTOX)
bordeaux.countrySK
bordeaux.title.proceedingToxicology Letters
bordeaux.conference.cityBratislava
bordeaux.peerReviewedoui
hal.identifierhal-01603238
hal.version1
hal.invitednon
hal.proceedingsoui
hal.conference.end2017-09-13
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01603238v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.btitle=Toxicology%20Letters&rft.date=2017&rft.volume=280,%20Supplement%201,%20Special%20Issue%20SI&rft.spage=np&rft.epage=np&rft.au=SALLES,%20Bernard&ROGOWSKY,%20Peter&FORGET,%20Florence&MOING,%20Annick&SERVIEN,%20R%C3%A9mi&rft.genre=unknown


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