hal.structure.identifier | ToxAlim [ToxAlim] | |
dc.contributor.author | SALLES, Bernard | |
hal.structure.identifier | Reproduction et développement des plantes [RDP] | |
dc.contributor.author | ROGOWSKY, Peter | |
hal.structure.identifier | Unité de recherche Mycologie et Sécurité des Aliments [MycSA] | |
dc.contributor.author | FORGET, Florence | |
hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
dc.contributor.author | MOING, Annick | |
hal.structure.identifier | ToxAlim [ToxAlim] | |
dc.contributor.author | SERVIEN, Rémi | |
hal.structure.identifier | Prévention et promotion de la cancérogénèse par les aliments [ToxAlim-PPCA] | |
dc.contributor.author | PRIYMENKO, Nathalie | |
hal.structure.identifier | MetaToul AXIOM [E20] | |
dc.contributor.author | CANLET, Cécile | |
hal.structure.identifier | Transcriptomic impact of Xenobiotics [E23 TRiX] | |
dc.contributor.author | LIPPI, Yannick | |
hal.structure.identifier | Methodomics | |
dc.contributor.author | LE GALL, Caroline | |
hal.structure.identifier | U 699 | |
dc.contributor.author | BERTHELOT, Laureline | |
hal.structure.identifier | Profilomic [Boulogne-Billancourt] | |
dc.contributor.author | CORMAN, Bruno | |
hal.structure.identifier | Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes [GERHM] | |
hal.structure.identifier | École des Hautes Études en Santé Publique [EHESP] [EHESP] | |
hal.structure.identifier | Institut de recherche en santé, environnement et travail [Irset] | |
dc.contributor.author | JEGOU, Bernard | |
hal.structure.identifier | ToxAlim [ToxAlim] | |
dc.contributor.author | CRAVEDI, Jean Pierre | |
hal.structure.identifier | Laboratoire d'étude des Résidus et Contaminants dans les Aliments [LABERCA] | |
dc.contributor.author | ANTIGNAC, Jean-Philippe | |
hal.structure.identifier | Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124] | |
hal.structure.identifier | Université Paris Descartes - Paris 5 [UPD5] | |
dc.contributor.author | BAROUKI, Robert | |
hal.structure.identifier | ToxAlim [ToxAlim] | |
dc.contributor.author | ARNICH, Nathalie | |
hal.structure.identifier | ToxAlim [ToxAlim] | |
dc.contributor.author | DANDERE-ABDOULKARIM, Kadidiatou | |
hal.structure.identifier | ToxAlim [ToxAlim] | |
dc.contributor.author | FERRIER, Laurent | |
hal.structure.identifier | ToxAlim [ToxAlim] | |
dc.contributor.author | BROUX, Bérengère | |
hal.structure.identifier | Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124] | |
hal.structure.identifier | Université Paris Descartes - Paris 5 [UPD5] | |
dc.contributor.author | COUMOUL, Xavier | |
dc.date.issued | 2017 | |
dc.date.conference | 2017-09-10 | |
dc.description.abstractEn | Wistar rats were fed during 6 months with 33% maize, either non genetically modified or containing MON810 or NK603 (11% and 33%). Extensive chemical analysis by MS and NMR profiling and targeted analyses were undertaken to qualify the harvests and quantify in maize and pellets macro- and micronutrients, anti-nutrients and undesirable substances and contaminants. All diets contained low levels (50 to 100 fold lower than the MRL values) of undesirable substances. Thirty rats per gender were fed with 8 different diets: MON810 (11% and 33%) plus isogenic control, NK603 (11% and 33% ± glyphosate treatment) and isogenic control. Rats were sacrificed after 3 months (sub-group A, 10 rats per diet, per gender) and 6 months (sub-group B, 12 rats and C, 8 rats per diet, per gender). Urine were collected in metabolic cages and blood at 90 (sub-group A), 90/135/180 (sub-group B) and 180 days of feeding (sub-group C). In addition to classical toxicological analysis we performed metabolomics and hormones quantification in blood and urine, transcriptomics on liver and kidney, gut barrier analysis, kidney and gonads targeted immunohistology. Statistical analyses were conducted first blindly and thereafter on the basis of relevant pair-wise comparison. We easily discriminate the rat gender or maize origin. Among the numerous statistically significant differences in pair-wise comparisons some concerned GMO and non-GMO, but no biological relevance could be established due to the lack of differences in biologically linked variables, dose-response effects or clinical disorders. | |
dc.language.iso | en | |
dc.source.title | Toxicology Letters | |
dc.title.en | Large scale studies of the influence of GMO-based corn diet after 6 months of consumption in Wistar rats | |
dc.type | Communication dans un congrès | |
dc.identifier.doi | 10.1016/j.toxlet.2017.07.297 | |
dc.subject.hal | Sciences du Vivant [q-bio] | |
bordeaux.page | np | |
bordeaux.volume | 280, Supplement 1, Special Issue SI | |
bordeaux.conference.title | 53. Congress of the European Societies of Toxicology (EUROTOX) | |
bordeaux.country | SK | |
bordeaux.title.proceeding | Toxicology Letters | |
bordeaux.conference.city | Bratislava | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01603238 | |
hal.version | 1 | |
hal.invited | non | |
hal.proceedings | oui | |
hal.conference.end | 2017-09-13 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01603238v1 | |
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