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Genome-wide association studies with proteomics data reveal genes important for synthesis, transport and packaging of globulins in legume seeds

hal.structure.identifierAgroécologie [Dijon]
dc.contributor.authorLE SIGNOR, Christine
hal.structure.identifierAgroécologie [Dijon]
dc.contributor.authorAIME, Delphine
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBORDAT, Amandine
hal.structure.identifierCentre de recherche en neurobiologie - neurophysiologie de Marseille [CRN2M]
dc.contributor.authorBELGHAZI, Maya
hal.structure.identifierPhysiologie de la reproduction et des comportements [Nouzilly] [PRC]
dc.contributor.authorLABAS, Valérie
hal.structure.identifierLaboratoire des interactions plantes micro-organismes [LIPM]
dc.contributor.authorGOUZY, Jerome
hal.structure.identifierDepartment of Plant Pathology
dc.contributor.authorYOUNG, Nevin D.
hal.structure.identifierAmélioration génétique et adaptation des plantes méditerranéennes et tropicales [UMR AGAP]
dc.contributor.authorPROSPERI, Jean-Marie
hal.structure.identifierInstitut de Recherche en Horticulture et Semences [IRHS]
dc.contributor.authorLEPRINCE, Olivier
hal.structure.identifierAgroécologie [Dijon]
dc.contributor.authorTHOMPSON, Richard
hal.structure.identifierInstitut de Recherche en Horticulture et Semences [IRHS]
dc.contributor.authorBUITINK, Julia
hal.structure.identifierAgroécologie [Dijon]
dc.contributor.authorBURSTIN, Judith
hal.structure.identifierAgroécologie [Dijon]
dc.contributor.authorGALLARDO-GUERRERO, Karine
dc.date.issued2017
dc.identifier.issn0028-646X
dc.description.abstractEnImproving nutritional seed quality is an important challenge in grain legume breeding. However, the genes controlling the differential accumulation of globulins, which are major contributors to seed nutritional value in legumes, remain largely unknown. We combined a search for protein quantity loci with genome-wide association studies on the abundance of 7S and 11S globulins in seeds of the model legume species Medicago truncatula. Identified genomic regions and genes carrying polymorphisms linked to globulin variations were then cross-compared with pea (Pisum sativum), leading to the identification of candidate genes for the regulation of globulin abundance in this crop. Key candidates identified include genes involved in transcription, chromatin remodeling, post-translational modifications, transport and targeting of proteins to storage vacuoles. Inference of a gene coexpression network of 12 candidate transcription factors and globulin genes revealed the transcription factor ABA-insensitive 5 (ABI5) as a highly connected hub. Characterization of loss-of-function abi5 mutants in pea uncovered a role for ABI5 in controlling the relative abundance of vicilin, a sulfur-poor 7S globulin, in pea seeds. This demonstrates the feasibility of using genome-wide association studies in M. truncatula to reveal genes that can be modulated to improve seed nutritional value.
dc.language.isoen
dc.publisherWiley
dc.subjectqualité des semences
dc.subjectamélioration génétique
dc.subjectlégume
dc.subjectsemence
dc.subject.enPisum sativum (pea)
dc.subject.enMedicago truncatula
dc.subject.engenome-wide association studies (GWAS)
dc.subject.englobulins
dc.subject.enlegumes
dc.subject.enprotein quantity loci (PQL)
dc.subject.enseed proteome
dc.subject.envegetable
dc.title.enGenome-wide association studies with proteomics data reveal genes important for synthesis, transport and packaging of globulins in legume seeds
dc.typeArticle de revue
dc.identifier.doi10.1111/nph.14500
dc.subject.halSciences du Vivant [q-bio]/Sciences agricoles
dc.subject.halSciences du Vivant [q-bio]/Biologie végétale
bordeaux.journalNew Phytologist
bordeaux.page1597-1613
bordeaux.volume214
bordeaux.issue4
bordeaux.peerReviewedoui
hal.identifierhal-01606529
hal.version1
hal.popularnon
hal.audienceNon spécifiée
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01606529v1
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