The shared role of the Rsr1 GTPase and Gic1/Gic2 in Cdc42 polarization.
| hal.structure.identifier | Department of Molecular Genetics | |
| dc.contributor.author | KANG, Pil Jung | |
| hal.structure.identifier | Ohio State University [Columbus] [OSU] | |
| dc.contributor.author | MILLER, Kristi E | |
| hal.structure.identifier | Department of Molecular Genetics | |
| dc.contributor.author | GUEGUENIAT, Julia | |
| hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
| hal.structure.identifier | Department of Molecular Genetics | |
| dc.contributor.author | BEVEN, Laure | |
| hal.structure.identifier | Department of Molecular Genetics | |
| dc.contributor.author | PARK, Hay-Oak | |
| dc.date.issued | 2018 | |
| dc.description.abstractEn | The Cdc42 GTPase plays a central role in polarity development in many species. In budding yeast, Cdc42 is essential for polarized growth at the proper site and also for spontaneous cell polarization in the absence of spatial cues. Cdc42 polarization is critical for multiple events in the G1 phase prior to bud emergence, including bud-site assembly, polarization of the actin cytoskeleton, and septin filament assembly to form a ring at the new bud site. Yet the mechanism by which Cdc42 polarizes is not fully understood. Here we report that biphasic Cdc42 polarization in the G1 phase is coupled to stepwise assembly of the septin ring for bud emergence. We show that the Rsr1 GTPase shares a partially redundant role with Gic1 and Gic2, two related Cdc42 effectors, in the first phase of Cdc42 polarization in haploid cells. We propose that the first phase of Cdc42 polarization is mediated by positive feedback loops that function in parallel-one involving Rsr1 via local activation of Cdc42 in response to spatial cues and another involving Gic1 or Gic2 via reduction of diffusion of active Cdc42. | |
| dc.language.iso | en | |
| dc.publisher | American Society for Cell Biology | |
| dc.title.en | The shared role of the Rsr1 GTPase and Gic1/Gic2 in Cdc42 polarization. | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1091/mbc.E18-02-0145 | |
| dc.subject.hal | Chimie/Autre | |
| dc.subject.hal | Chimie/Polymères | |
| bordeaux.journal | Molecular Biology of the Cell | |
| bordeaux.page | 2359-2369 | |
| bordeaux.volume | 29 | |
| bordeaux.issue | 20 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-02621075 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-02621075v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular%20Biology%20of%20the%20Cell&rft.date=2018&rft.volume=29&rft.issue=20&rft.spage=2359-2369&rft.epage=2359-2369&rft.au=KANG,%20Pil%20Jung&MILLER,%20Kristi%20E&GUEGUENIAT,%20Julia&BEVEN,%20Laure&PARK,%20Hay-Oak&rft.genre=article |
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