Mostrar el registro sencillo del ítem

STERILE APETALA modulates the stability of a repressor protein complex to control organ size in <em>Arabidopsis thaliana.</em>

hal.structure.identifierState Key Laboratory of Molecular Developmental Biology, Institute of genetics and developmental Biology, CAS
dc.contributor.authorLI, Na
hal.structure.identifierState Key Laboratory of Molecular Developmental Biology, Institute of genetics and developmental Biology, CAS
dc.contributor.authorLIU, Zupei
hal.structure.identifierState Key Laboratory of Molecular Developmental Biology, Institute of genetics and developmental Biology, CAS
dc.contributor.authorWANG, Zhibiao
hal.structure.identifierHebei Normal University
dc.contributor.authorRU, Licong
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierUniversiteit Gent = Ghent University = Université de Gand [UGENT]
dc.contributor.authorGONZALEZ, Nathalie
hal.structure.identifierUniversiteit Gent = Ghent University = Université de Gand [UGENT]
dc.contributor.authorBAEKELANDT, Alexandra
hal.structure.identifierUniversiteit Gent = Ghent University = Université de Gand [UGENT]
dc.contributor.authorPAUWELS, Laurens
hal.structure.identifierUniversiteit Gent = Ghent University = Université de Gand [UGENT]
dc.contributor.authorGOOSSENS, Alain
hal.structure.identifierState Key Laboratory of Molecular Developmental Biology, Institute of genetics and developmental Biology, CAS
dc.contributor.authorXU, Ran
hal.structure.identifierHebei Normal University
dc.contributor.authorZHU, Zhengge
hal.structure.identifierUniversiteit Gent = Ghent University = Université de Gand [UGENT]
dc.contributor.authorINZÉ, Dirk
hal.structure.identifierState Key Laboratory of Molecular Developmental Biology, Institute of genetics and developmental Biology, CAS
dc.contributor.authorLI, Yunhai
dc.date.issued2018
dc.identifier.issn1553-7390
dc.description.abstractEnOrgan size control is of particular importance for developmental biology and agriculture, but the mechanisms underlying organ size regulation remain elusive in plants. Meristemoids, which possess stem cell-like properties, have been recognized to play important roles in leaf growth. We have recently reported that the Arabidopsis F-box protein STERILE APETALA (SAP)/SUPPRESSOR OF DA1 (SOD3) promotes meristemoid proliferation and regulates organ size by influencing the stability of the transcriptional regulators PEAPODs (PPDs). Here we demonstrate that KIX8 and KIX9, which function as adaptors for the corepressor TOPLESS and PPD, are novel substrates of SAP. SAP interacts with KIX8/9 and modulates their protein stability. Further results show that SAP acts in a common pathway with KIX8/9 and PPD to control organ growth by regulating meristemoid cell proliferation. Thus, these findings reveal a molecular mechanism by which SAP targets the KIX-PPD repressor complex for degradation to regulate meristemoid cell proliferation and organ size.
dc.language.isoen
dc.publisherPublic Library of Science
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.title.enSTERILE APETALA modulates the stability of a repressor protein complex to control organ size in <em>Arabidopsis thaliana.</em>
dc.typeArticle de revue
dc.identifier.doi10.1371/journal.pgen.1007218
dc.subject.halSciences du Vivant [q-bio]/Biologie végétale
bordeaux.journalPLoS Genetics
bordeaux.pagee1007218
bordeaux.volume14
bordeaux.issue2
bordeaux.peerReviewedoui
hal.identifierhal-02625191
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02625191v1
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=PLoS%20Genetics&amp;rft.date=2018&amp;rft.volume=14&amp;rft.issue=2&amp;rft.spage=e1007218&amp;rft.epage=e1007218&amp;rft.eissn=1553-7390&amp;rft.issn=1553-7390&amp;rft.au=LI,%20Na&amp;LIU,%20Zupei&amp;WANG,%20Zhibiao&amp;RU,%20Licong&amp;GONZALEZ,%20Nathalie&amp;rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem