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Frataxin Is Localized to Both the Chloroplast and Mitochondrion and Is Involved in Chloroplast Fe-S Protein Function in Arabidopsis.

hal.structure.identifierUniversidad Nacional de Rosario [Santa Fe]
dc.contributor.authorTUROWSKI, Valeria R
hal.structure.identifierCentre National de la Recherche Scientifique [CNRS]
dc.contributor.authorAKNIN, Cindy
hal.structure.identifierUniversidad Nacional de San Martin [UNSAM]
dc.contributor.authorMALIANDI, María V
hal.structure.identifierUniversidad Nacional de Rosario [Santa Fe]
dc.contributor.authorBUCHENSKY, Celeste
hal.structure.identifierUniversidad Nacional de Rosario [Santa Fe]
dc.contributor.authorLEADEN, Laura
hal.structure.identifierUniversidad Nacional de Rosario [Santa Fe]
dc.contributor.authorPERALTA, Diego A
hal.structure.identifierUniversidad Nacional de Rosario [Santa Fe]
dc.contributor.authorBUSI, Maria V
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorARAYA, Alejandro
hal.structure.identifierUniversidad Nacional de Rosario [Santa Fe]
dc.contributor.authorGOMEZ-CASATI, Diego F
dc.date.issued2015
dc.identifier.issn1932-6203
dc.description.abstractEnFrataxin plays a key role in eukaryotic cellular iron metabolism, particularly in mitochondrial heme and iron-sulfur (Fe-S) cluster biosynthesis. However, its precise role has yet to be elucidated. In this work, we studied the subcellular localization of Arabidopsis frataxin, AtFH, using confocal microscopy, and found a novel dual localization for this protein. We demonstrate that plant frataxin is targeted to both the mitochondria and the chloroplast, where it may play a role in Fe-S cluster metabolism as suggested by functional studies on nitrite reductase (NIR) and ferredoxin (Fd), two Fe-S containing chloroplast proteins, in AtFH deficient plants. Our results indicate that frataxin deficiency alters the normal functioning of chloroplasts by affecting the levels of Fe, chlorophyll, and the photosynthetic electron transport chain in this organelle.
dc.language.isoen
dc.publisherPublic Library of Science
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.title.enFrataxin Is Localized to Both the Chloroplast and Mitochondrion and Is Involved in Chloroplast Fe-S Protein Function in Arabidopsis.
dc.typeArticle de revue
dc.identifier.doi10.1371/journal.pone.0141443
dc.subject.halSciences du Vivant [q-bio]/Biologie végétale
bordeaux.journalPLoS ONE
bordeaux.pagee0141443
bordeaux.volume10
bordeaux.issue10
bordeaux.peerReviewedoui
hal.identifierhal-02634174
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02634174v1
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