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Mycoplasma mycoides, from "mycoides Small Colony" to "capri". A microevolutionary perspective

hal.structure.identifierContrôle des maladies animales exotiques et émergentes [UMR CMAEE]
dc.contributor.authorTHIAUCOURT, François
hal.structure.identifierContrôle des maladies animales exotiques et émergentes [UMR CMAEE]
dc.contributor.authorMANSO-SILVÁN, Lucía
hal.structure.identifierContrôle des maladies animales exotiques et émergentes [UMR CMAEE]
dc.contributor.authorSALAH, Woubit
hal.structure.identifierCommissariat à l'énergie atomique et aux énergies alternatives [CEA]
dc.contributor.authorBARBE, Valérie
hal.structure.identifierCommissariat à l'énergie atomique et aux énergies alternatives [CEA]
dc.contributor.authorVACHERIE, Benoit
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorJACOB, Daniel
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBRETON, Marc
hal.structure.identifierContrôle des maladies animales exotiques et émergentes [UMR CMAEE]
dc.contributor.authorDUPUY, Virginie
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorLOMENECH, Anne Marie
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBLANCHARD, Alain
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorSIRAND-PUGNET, Pascal
dc.date.issued2011
dc.identifier.issn1471-2164
dc.description.abstractEnBackground The Mycoplasma mycoides cluster consists of five species or subspecies that are ruminant pathogens. One subspecies, Mycoplasma mycoides subspecies mycoides Small Colony (MmmSC), is the causative agent of contagious bovine pleuropneumonia. Its very close relative, Mycoplasma mycoides subsp. capri (Mmc), is a more ubiquitous pathogen in small ruminants causing mastitis, arthritis, keratitis, pneumonia and septicaemia and is also found as saprophyte in the ear canal. To understand the genetics underlying these phenotypic differences, we compared the MmmSC PG1 type strain genome, which was already available, with the genome of an Mmc field strain (95010) that was sequenced in this study. We also compared the 95010 genome with the recently published genome of another Mmc strain (GM12) to evaluate Mmc strain diversity. Results The MmmSC PG1 genome is 1,212 kbp and that of Mmc 95010 is ca. 58 kbp shorter. Most of the sequences present in PG1 but not 95010 are highly repeated Insertion Sequences (three types of IS) and large duplicated DNA fragments. The 95010 genome contains five types of IS, present in fewer copies than in PG1, and two copies of an integrative conjugative element. These mobile genetic elements have played a key role in genome plasticity, leading to inversions of large DNA fragments. Comparison of the two genomes suggested a marked decay of the PG1 genome that seems to be correlated with a greater number of IS. The repertoire of gene families encoding surface proteins is smaller in PG1. Several genes involved in polysaccharide metabolism and protein degradation are also absent from, or degraded in, PG1. Conclusions The genome of MmmSC PG1 is larger than that of Mmc 95010, its very close relative, but has less coding capacity. This is the result of large genetic rearrangements due to mobile elements that have also led to marked gene decay. This is consistent with a non-adaptative genomic complexity theory, allowing duplications or pseudogenes to be maintained in the absence of adaptive selection that would lead to purifying selection and genome streamlining over longer evolutionary times. These findings also suggest that MmmSC only recently adapted to its bovine host.
dc.language.isoen
dc.publisherBioMed Central
dc.subjectGENOMIQUE
dc.subjectGENETIQUE
dc.subjectCAPRI
dc.subject.enMYCOIDES SMALL COLONY
dc.title.enMycoplasma mycoides, from "mycoides Small Colony" to "capri". A microevolutionary perspective
dc.typeArticle de revue
dc.identifier.doi10.1186/1471-2164-12-114
dc.subject.halSciences du Vivant [q-bio]/Génétique
bordeaux.journalBMC Genomics
bordeaux.page114 : 1-19
bordeaux.volume12
bordeaux.peerReviewedoui
hal.identifierhal-02643828
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02643828v1
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