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Contagious Bovine and Caprine Pleuropneumonia: a research community's recommendations for the development of better vaccines

hal.structure.identifierUniversität Bern = University of Bern = Université de Berne [UNIBE]
dc.contributor.authorJORES, Joerg
hal.structure.identifierUniversity of Massachusetts [Amherst] [UMass Amherst]
dc.contributor.authorBALDWIN, Cynthia
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBLANCHARD, Alain
hal.structure.identifierUniversity of Melbourne
dc.contributor.authorBROWNING, Glenn
hal.structure.identifierGlobal Alliance for Livestock Veterinary Medicines
dc.contributor.authorCOLSTON, Angie
hal.structure.identifierVaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac)
dc.contributor.authorGERDTS, Volker
hal.structure.identifierGlobal Alliance for Livestock Veterinary Medicines
dc.contributor.authorGOOVAERTS, Danny
hal.structure.identifierFederal Research Institute for Animal Health - Friedrich-Loeffler-Institut
dc.contributor.authorHELLER, Martin
hal.structure.identifierBill & Melinda Gates Foundation [Seattle]
dc.contributor.authorJULEFF, Nick
hal.structure.identifierUniversität Bern = University of Bern = Université de Berne [UNIBE]
dc.contributor.authorLABROUSSAA, Fabien
hal.structure.identifierInternational Livestock Research Institute [CGIAR, Nairobi] [ILRI]
dc.contributor.authorLILJANDER, Anne
hal.structure.identifierUniversity of Zambia [Lusaka] [UNZA]
dc.contributor.authorMUUKA, Geoffrey
hal.structure.identifierInternational Livestock Research Institute [CGIAR, Nairobi] [ILRI]
dc.contributor.authorNENE, Vish
hal.structure.identifierHadassah Hebrew University Medical Center [Jerusalem]
dc.contributor.authorNIR-PAZ, Ran
hal.structure.identifierIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise Guiseppe Caporale [IZSAM]
dc.contributor.authorSACCHINI, Flavio
hal.structure.identifierInstitute of Virology and Immunology [Mittelhäusern] [IVI]
dc.contributor.authorSUMMERFIELD, Artur
hal.structure.identifierAnimal, Santé, Territoires, Risques et Ecosystèmes [UMR ASTRE]
hal.structure.identifierDépartement Systèmes Biologiques [Cirad-BIOS]
dc.contributor.authorTHIAUCOURT, François
hal.structure.identifierJoint FAO/IAEA Programme - Nuclear Techniques in Food and Agriculture
dc.contributor.authorUNGER, Hermann
hal.structure.identifierJ. Craig Venter Institute
dc.contributor.authorVASHEE, Sanjay
hal.structure.identifierChinese Academy of Agricultural Sciences [CAAS]
dc.contributor.authorWANG, Xiumei
hal.structure.identifierGlobal Alliance for Livestock Veterinary Medicines
dc.contributor.authorSALT, Jeremy
dc.date.issued2020
dc.description.abstractEnContagious bovine pleuropneumonia (CBPP) and contagious caprine pleuropneumonia (CCPP) are major infectious diseases of ruminants caused by mycoplasmas in Africa and Asia. In contrast with the limited pathology in the respiratory tract of humans infected with mycoplasmas, CBPP and CCPP are devastating diseases associated with high morbidity and mortality. Beyond their obvious impact on animal health, CBPP and CCPP negatively impact the livelihood and wellbeing of a substantial proportion of livestock-dependent people affecting their culture, economy, trade and nutrition. The causative agents of CBPP and CCPP are Mycoplasma mycoides subspecies mycoides and Mycoplasma capricolum subspecies capripneumoniae, respectively, which have been eradicated in most of the developed world. The current vaccines used for disease control consist of a live attenuated CBPP vaccine and a bacterin vaccine for CCPP, which were developed in the 1960s and 1980s, respectively. Both of these vaccines have many limitations, so better vaccines are urgently needed to improve disease control. In this article the research community prioritized biomedical research needs related to challenge models, rational vaccine design and protective immune responses. Therefore, we scrutinized the current vaccines as well as the challenge-, pathogenicity-and immunity models. We highlight research gaps and provide recommendations towards developing safer and more efficacious vaccines against CBPP and CCPP. npj Vaccines (2020) 5:66 ; https://doi.
dc.language.isoen
dc.publisherNature Research
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subjectPleuropneumonie bobine
dc.subjectPleuropneumonie caprine
dc.subjectVaccin
dc.subjectruminant
dc.subjectMycoplasma mycoides subspecies mycoides
dc.subjectMycoplasma capricolum subsp capripneumoniae
dc.subjectpathologie animale
dc.subjectMycoplasme
dc.subjectImmunologie
dc.title.enContagious Bovine and Caprine Pleuropneumonia: a research community's recommendations for the development of better vaccines
dc.typeArticle de revue
dc.identifier.doi10.1038/s41541-020-00214-2
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halSciences du Vivant [q-bio]/Biologie animale
dc.subject.halSciences du Vivant [q-bio]/Biologie animale/Médecine vétérinaire et santé animal
bordeaux.journalNPJ vaccines
bordeaux.page66
bordeaux.volume5
bordeaux.issue1
bordeaux.peerReviewedoui
hal.identifierhal-02915032
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02915032v1
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