Exploring Spiroplasma Biology: Opportunities and Challenges
| hal.structure.identifier | Indian Institute of Science Education and Research Pune [IISER Pune] | |
| dc.contributor.author | HARNE, Shrikant | |
| hal.structure.identifier | Indian Institute of Science Education and Research Pune [IISER Pune] | |
| dc.contributor.author | GAYATHRI, Pananghat | |
| hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
| dc.contributor.author | BÉVEN, Laure | |
| dc.date.issued | 2020 | |
| dc.identifier.issn | 1664-302X | |
| dc.description.abstractEn | Spiroplasmas are cell-wall-deficient helical bacteria belonging to the class Mollicutes. Their ability to maintain a helical shape in the absence of cell wall and their motility in the absence of external appendages have attracted attention from the scientific community for a long time. In this review we compare and contrast motility, shape determination and cytokinesis mechanisms of Spiroplasma with those of other Mollicutes and cellwalled bacteria. The current models for rod-shape determination and cytokinesis in cell-walled bacteria propose a prominent role for the cell wall synthesis machinery. These models also involve the cooperation of the actin-like protein MreB and FtsZ, the bacterial homolog of tubulin. However the exact role of the cytoskeletal proteins is still under much debate. Spiroplasma possess MreBs, exhibit a rod-shape dependent helical morphology, and divide by an FtsZ-dependent mechanism. Hence, spiroplasmas represent model organisms for deciphering the roles of MreBs and FtsZ in fundamental mechanisms of non-spherical shape determination and cytokinesis in bacteria, in the absence of a cell wall. Identification of components implicated in these processes and deciphering their functions would require genetic experiments. Challenges in genetic manipulations in spiroplasmas are a major bottleneck in understanding their biology. We discuss advancements in genome sequencing, gene editing technologies, superresolution microscopy and electron cryomicroscopy and tomography, which can be employed for addressing long-standing questions related to Spiroplasma biology. | |
| dc.language.iso | en | |
| dc.publisher | Frontiers Media | |
| dc.rights.uri | http://creativecommons.org/licenses/by/ | |
| dc.subject | Mollicute | |
| dc.subject | bactérie phytopathogène | |
| dc.subject.en | Spiroplasma | |
| dc.subject.en | shape determination | |
| dc.subject.en | motility | |
| dc.subject.en | bacterial cytoskeleton | |
| dc.subject.en | fibril | |
| dc.subject.en | MreB | |
| dc.subject.en | Spiroplasma genetics | |
| dc.subject.en | bacterial division | |
| dc.title.en | Exploring Spiroplasma Biology: Opportunities and Challenges | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.3389/fmicb.2020.589279 | |
| dc.subject.hal | Sciences du Vivant [q-bio] | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biologie végétale | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biologie végétale/Phytopathologie et phytopharmacie | |
| bordeaux.journal | Frontiers in Microbiology | |
| bordeaux.page | 589279 | |
| bordeaux.volume | 11 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-03035739 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-03035739v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Microbiology&rft.date=2020&rft.volume=11&rft.spage=589279&rft.epage=589279&rft.eissn=1664-302X&rft.issn=1664-302X&rft.au=HARNE,%20Shrikant&GAYATHRI,%20Pananghat&B%C3%89VEN,%20Laure&rft.genre=article |
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