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Correction to : MRSI vs CEST MRI to understand tomato metabolism in ripening fruit: is there a better contrast ?

hal.structure.identifierQualité des Produits Animaux [QuaPA]
dc.contributor.authorPAGÉS, Guilhem
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorDEBORDE, Catherine
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorLEMAIRE-CHAMLEY, Martine
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorMOING, Annick
hal.structure.identifierQualité des Produits Animaux [QuaPA]
dc.contributor.authorBONNY, Jean-Marie
dc.date.issued2021-03
dc.identifier.issn1618-2642
dc.description.abstractEnBackground Processed meat intake is associated with a higher risk of colorectal and stomach cancers, coronary artery disease, and type 2 diabetes and with higher mortality, but the estimation of intake of different processed meat products in this heterogeneous food group in epidemiological studies remains challenging. Objective This work aimed at identifying novel biomarkers for processed meat intake using metabolomics. Methods An untargeted, multi-tiered metabolomics approach based on LC-MS was applied to 33 meat products digested in vitro and secondly to urine and plasma samples from a randomized crossover dietary intervention in which 12 volunteers consumed successively 3 processed meat products (bacon, salami, and hot dog) and 2 other foods used as controls, over 3 consecutive days. The putative biomarkers were then measured in urine from 474 subjects from the European Prospective Investigation into Cancer and Nutrition (EPIC) cross-sectional study for which detailed 24-h dietary recalls and FFQs were available. Results Syringol and 4 derivatives of syringol were found to be characteristic of in vitro digests of smoked meat products. The same compounds present as sulfate esters in urine increased at 2 and 12 h after consumption of smoked meat products (hot dog, bacon) in the intervention study. The same syringol sulfates were also positively associated with recent or habitual consumption of smoked meat products in urine samples from participants of the EPIC cross-sectional study. These compounds showed good discriminative ability for smoked meat intake with receiver operator characteristic areas under the curve ranging from 0.78 to 0.86 and 0.74 to 0.79 for short-term and habitual intake, respectively. Conclusions Four novel syringol sulfates were identified as potential biomarkers of smoked meat intake and may be used to improve assessment of smoked meat intake in epidemiological studies. This trial was registered at clinicaltrials.gov as NCT03354130.
dc.language.isoen
dc.publisherSpringer Verlag
dc.subject.enChemical exchange saturation transfer (CEST)
dc.subject.enMagnetic resonance spectroscopy imaging (MRSI)
dc.subject.enMetabolites
dc.subject.enRipe
dc.subject.enfruit
dc.subject.enSugars Tomato
dc.title.enCorrection to : MRSI vs CEST MRI to understand tomato metabolism in ripening fruit: is there a better contrast ?
dc.typeArticle de revue
dc.identifier.doi10.1007/s00216-021-03180-3
dc.subject.halChimie
bordeaux.journalAnalytical and Bioanalytical Chemistry
bordeaux.page1777-1777
bordeaux.volume413
bordeaux.issue6
bordeaux.peerReviewedoui
hal.identifierhal-03297107
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03297107v1
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