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hal.structure.identifierCenter for Integrative Physiology and Molecular Medicine
dc.contributor.authorZHOU, Xiao
hal.structure.identifierCenter for Integrative Physiology and Molecular Medicine
dc.contributor.authorZHAO, Renping
hal.structure.identifierDepartment of Theoretical Physics [Saarbrücken]
dc.contributor.authorSCHWARZ, Karsten
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
hal.structure.identifierDepartment of Theoretical Physics [Saarbrücken]
dc.contributor.authorMANGEAT, Matthieu
hal.structure.identifierCenter for Integrative Physiology and Molecular Medicine
dc.contributor.authorSCHWARZ, Eva C.
hal.structure.identifierCenter for Bioinformatics [Saarbrücken]
hal.structure.identifierInstitute for Biostatistics and Informatics in Medicine and Ageing Research
dc.contributor.authorHAMED, Mohamed
hal.structure.identifierMolecular Physiology, Institute of Cardiovascular Physiology
dc.contributor.authorBOGESKI, Ivan
hal.structure.identifierCenter for Bioinformatics [Saarbrücken]
dc.contributor.authorHELMS, Volkhard
hal.structure.identifierDepartment of Theoretical Physics [Saarbrücken]
dc.contributor.authorRIEGER, Heiko
hal.structure.identifierCenter for Integrative Physiology and Molecular Medicine
dc.contributor.authorQU, Bin
dc.date.created2016-05-27
dc.date.issued2017
dc.identifier.issn2045-2322
dc.description.abstractEnNatural killer (NK) cells play a central role during innate immune responses by eliminating pathogen-infected or tumorigenic cells. In the microenvironment, NK cells encounter not only target cells but also other cell types including non-target bystander cells. The impact of bystander cells on NK killing efficiency is, however, still elusive. In this study we show that the presence of bystander cells, such as P815, monocytes or HUVEC, enhances NK killing efficiency. With bystander cells present, the velocity and persistence of NK cells were increased, whereas the degranulation of lytic granules remained unchanged. Bystander cell-derived H 2 O 2 was found to mediate the acceleration of NK cell migration. Using mathematical diffusion models, we confirm that local acceleration of NK cells in the vicinity of bystander cells reduces their search time to locate target cells. In addition, we found that integrin β chains (β1, β2 and β7) on NK cells are required for bystander-enhanced NK migration persistence. In conclusion, we show that acceleration of NK cell migration in the vicinity of H 2 O 2-producing bystander cells reduces target cell search time and enhances NK killing efficiency.
dc.language.isoen
dc.publisherNature Publishing Group
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.title.enBystander cells enhance NK cytotoxic efficiency by reducing search time
dc.typeArticle de revue
dc.identifier.doi10.1038/srep44357
dc.subject.halSciences du Vivant [q-bio]/Immunologie/Immunité innée
bordeaux.journalScientific Reports
bordeaux.page44357
bordeaux.volume7
bordeaux.peerReviewedoui
hal.identifierhal-01514190
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01514190v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2017&rft.volume=7&rft.spage=44357&rft.epage=44357&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=ZHOU,%20Xiao&ZHAO,%20Renping&SCHWARZ,%20Karsten&MANGEAT,%20Matthieu&SCHWARZ,%20Eva%20C.&rft.genre=article


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