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Ultrafast dynamics and Raman imaging of metal complexes of tetrasulphonated phthalocyanines in human cancerous and noncancerous breast tissues

hal.structure.identifierLaboratory of Laser Molecular Spectroscopy [Lodz] [LLMS]
dc.contributor.authorABRAMCZYK, H.
hal.structure.identifierLaboratory of Laser Molecular Spectroscopy [Lodz] [LLMS]
dc.contributor.authorJAROTA, A.
hal.structure.identifierLaboratory of Laser Molecular Spectroscopy [Lodz] [LLMS]
dc.contributor.authorBROZEK-PLUSKA, B.
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorTONDUSSON, M.
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorFREYSZ, E.
hal.structure.identifierDepartment of Molecular Pathology and Neuropathology
dc.contributor.authorMUSIAL, J.
hal.structure.identifierDepartment of Molecular Pathology and Neuropathology
dc.contributor.authorKORDEK, R.
dc.date.issued2013
dc.date.conference2012-07-08
dc.description.abstractEnA promising material in medicine, electronics, optoelectronics, electrochemistry, catalysis and photophysics, Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS4) is investigated at biological interfaces of human breast tissue by means of time-resolved spectroscopy. The nature of fast processes and pathways of the competing relaxation mechanisms from the initially excited electronic states of a photosensitizer at biological interfaces have been studied. Comparison between the results in the biological environment of the breast tissues and in aqueous solutions demonstrates that the photochemical mechanisms become dramatically different. The presented results provide a basis for a substantial revision of the commonly accepted assumption that photochemistry of the bulk properties of photosensitizers in solutions can be translated to the interfacial region. First, in solution the dynamics of the photosensitizer is much slower than that at the biological interface. Second, the dynamics of the photosensitizer in the cancerous tissue is dramatically slower than that in noncancerous tissue. Our results provide evidence that molecular structures responsible for harvesting of the light energy in biological tissue find their ways for a recovery through some special features of the potential energy surfaces such as conical intersections, which facilitate the rate of radiationless transitions and maintain the photostability in the biological systems.
dc.language.isoen
dc.title.enUltrafast dynamics and Raman imaging of metal complexes of tetrasulphonated phthalocyanines in human cancerous and noncancerous breast tissues
dc.typeCommunication dans un congrès avec actes
dc.identifier.doi10.1051/epjconf/20134107006
dc.subject.halPhysique [physics]
dc.subject.halPhysique [physics]/Physique [physics]/Optique [physics.optics]
bordeaux.volume41
bordeaux.countryCH
bordeaux.title.proceeding18th International Conference on Ultrafast Phenomena
bordeaux.conference.cityLausanne
bordeaux.peerReviewednon
hal.identifierhal-01555673
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01555673v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2013&rft.volume=41&rft.au=ABRAMCZYK,%20H.&JAROTA,%20A.&BROZEK-PLUSKA,%20B.&TONDUSSON,%20M.&FREYSZ,%20E.&rft.genre=proceeding


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