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New Melting Data of the Two Polymorphs of Prednisolone

hal.structure.identifierUnité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)]
dc.contributor.authorCORVIS, Yohann
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorNÉGRIER, Philippe
hal.structure.identifierDépartement Technologie des Polymères et Composites & Ingénierie Mécanique [TPCIM]
dc.contributor.authorSOULESTIN, Jérémie
hal.structure.identifierUnité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1022)]
dc.contributor.authorESPEAU, Philippe
dc.date.created2016-07-22
dc.date.issued2016
dc.identifier.issn1520-6106
dc.description.abstractEnPrednisolone is known to exist in two anhydrous solid polymorphic forms. The substance is known to degrade upon melting, resulting in erroneous melting data, as shown by the widely scattered results reported in the literature. In this article, thermal analyses carried out at different scan rates show that the onset temperature and the enthalpy value of the signal increase with the scan rate and reach plateau values for high scan rates. Owing to flash scanning calorimetry, the plateau value for the temperature has been identified as the “true” temperature of melting of both polymorphs. This consistent set of new thermodynamic data on the two solid forms leads to the conclusion that both forms are unambiguously enantiotropes of each other. The solid–solid transition has been observed experimentally for the first time and has been confirmed by calculation.
dc.description.sponsorshipNucléation à l'échèle nanométrique induite par lumière polarisée. Contrôle du polymorphisme cristallin : Application aux principes actifs pharmaceutiques - ANR-10-NANO-0017
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/
dc.title.enNew Melting Data of the Two Polymorphs of Prednisolone
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.jpcb.6b07349
dc.subject.halChimie/Cristallographie
dc.subject.halChimie/Chimie théorique et/ou physique
bordeaux.journalJournal of Physical Chemistry B
bordeaux.page10839-10843
bordeaux.volume120
bordeaux.issue41
bordeaux.peerReviewedoui
hal.identifierhal-01397339
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01397339v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Physical%20Chemistry%20B&rft.date=2016&rft.volume=120&rft.issue=41&rft.spage=10839-10843&rft.epage=10839-10843&rft.eissn=1520-6106&rft.issn=1520-6106&rft.au=CORVIS,%20Yohann&N%C3%89GRIER,%20Philippe&SOULESTIN,%20J%C3%A9r%C3%A9mie&ESPEAU,%20Philippe&rft.genre=article


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