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A multiscale mathematical model of avascular tumor growth to investigate the therapeutic benefit of anti-invasive agents

hal.structure.identifierNumerical Medicine [NUMED]
dc.contributor.authorRIBBA, Benjamin
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation, contrôle et calcul [MC2]
dc.contributor.authorSAUT, Olivier
hal.structure.identifierModélisation, contrôle et calcul [MC2]
dc.contributor.authorCOLIN, Thierry
hal.structure.identifierLaboratoire de Mathématiques [LAMA]
dc.contributor.authorBRESCH, Didier
hal.structure.identifierUnité de Mathématiques Pures et Appliquées [UMPA-ENSL]
hal.structure.identifierNumerical Medicine [NUMED]
dc.contributor.authorGRENIER, Emmanuel
hal.structure.identifierEvaluation et modélisation des effets thérapeutiques [LBBE]
dc.contributor.authorBOISSEL, Jean-Pierre
dc.date.created2006
dc.date.issued2006
dc.identifier.issn0022-5193
dc.description.abstractEnWith the aim of inhibiting cancer growth and reducing the risk of metastasis, pharmaceutical companies in the early 1990s developed anti-metastatic agents called inhibitors of metalloproteinases (MMPi). Despite the promising results obtained in pre-clinical studies, results of Phase III trials have been somewhat disappointing for late stage cancer patients. With the aim of mathematically investigating this therapeutic failure, we developed a mechanistically based model which integrates cell cycle regulation and macroscopic tumor dynamics. By simulating the model, we evaluated the efficacy of MMPi therapy. Simulation results predict the lack of efficacy of MMPi in advanced cancer patients. The theoretical model may aid in evaluating the efficacy of anti-metastatic therapies, thus benefiting the design of prospective clinical trials.
dc.language.isoen
dc.publisherElsevier
dc.title.enA multiscale mathematical model of avascular tumor growth to investigate the therapeutic benefit of anti-invasive agents
dc.typeArticle de revue
dc.identifier.doi10.1016/j.jtbi.2006.07.013
dc.subject.halMathématiques [math]/Equations aux dérivées partielles [math.AP]
dc.subject.halInformatique [cs]/Modélisation et simulation
dc.subject.halSciences du Vivant [q-bio]/Cancer
bordeaux.journalJournal of Theoretical Biology
bordeaux.page532-541
bordeaux.volume243
bordeaux.issue4
bordeaux.peerReviewedoui
hal.identifierinria-00332464
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//inria-00332464v1
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