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Multifractal Desynchronization of the Cardiac Excitable Cell Network During Atrial Fibrillation. II. Modeling

hal.structure.identifierGeometry and Statistics in acquisition data [GeoStat]
dc.contributor.authorATTUEL, Guillaume
hal.structure.identifierInstitute of Continuous Media Mechanics of the RAS [ICMM]
dc.contributor.authorGERASIMOVA-CHECHKINA, Evgeniya
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
dc.contributor.authorARGOUL, Françoise
hal.structure.identifierGeometry and Statistics in acquisition data [GeoStat]
dc.contributor.authorYAHIA, Hussein
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
dc.contributor.authorARNEODO, Alain
dc.date.issued2019
dc.identifier.issn1664-042X
dc.description.abstractEnIn a companion paper (I. Multifractal analysis of clinical data), we used a wavelet-based multiscale analysis to reveal and quantify the multifractal intermittent nature of the cardiac impulse energy in the low frequency range 2Hz during atrial fibrillation (AF). It demarcated two distinct areas within the coronary sinus (CS) with regionally stable multifractal spectra likely corresponding to different anatomical substrates. The electrical activity also showed no sign of the kind of temporal correlations typical of cascading processes across scales, thereby indicating that the multifractal scaling is carried by variations in the large amplitude oscillations of the recorded bipolar electric potential. In the present study, to account for these observations, we explore the role of the kinetics of gap junction channels (GJCs), in dynamically creating a new kind of imbalance between depolarizing and repolarizing currents. We propose a one-dimensional (1D) spatial model of a denervated myocardium, where the coupling of cardiac cells fails to synchronize the network of cardiac cells because of abnormal transjunctional capacitive charging of GJCs. We show that this non-ohmic nonlinear conduction 1D modeling accounts quantitatively well for the "multifractal random noise" dynamics of the electrical activity experimentally recorded in the left atrial posterior wall area. We further demonstrate that the multifractal properties of the numerical impulse energy are robust to changes in the model parameters.
dc.language.isoen
dc.publisherFrontiers
dc.subject.enExcitable cell network
dc.subject.enModeling
dc.subject.enIntermittent dynamics
dc.subject.enAtrial fibrillation
dc.subject.enMultifractal analysis
dc.subject.enKinetics of gap junction channel
dc.title.enMultifractal Desynchronization of the Cardiac Excitable Cell Network During Atrial Fibrillation. II. Modeling
dc.typeArticle de revue
dc.identifier.doi10.3389/fphys.2019.00480
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
dc.subject.halPhysique [physics]/Physique [physics]/Physique Médicale [physics.med-ph]
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
bordeaux.journalFrontiers in Physiology
bordeaux.page480
bordeaux.volume10
bordeaux.peerReviewedoui
hal.identifierhal-02108521
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02108521v1
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