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Endocytic Trafficking and Recycling Maintain a Pool of Mobile Surface AMPA Receptors Required for Synaptic Potentiation

hal.structure.identifierPhysiologie cellulaire de la synapse [PCS]
hal.structure.identifierDepartment of Neuroscience and Brain Technology
dc.contributor.authorPETRINI, Enrica Maria
hal.structure.identifierDepartment of Neurobiology
dc.contributor.authorLU, Jiuyi
hal.structure.identifierCentre de physique moléculaire optique et hertzienne [CPMOH]
dc.contributor.authorCOGNET, Laurent
hal.structure.identifierCentre de physique moléculaire optique et hertzienne [CPMOH]
dc.contributor.authorLOUNIS, Brahim
hal.structure.identifierDepartment of Neurobiology
hal.structure.identifierHoward Hughes Medical Institute [HHMI]
dc.contributor.authorEHLERS MICHAEL, D.
hal.structure.identifierPhysiologie cellulaire de la synapse [PCS]
dc.contributor.authorCHOQUET, Daniel
dc.date.issued2009-07-16
dc.identifier.issn0896-6273
dc.description.abstractEnAt excitatory glutamatergic synapses, postsynaptic endocytic zones (EZs), which are adjacent to the postsynaptic density (PSD), mediate clathrin-dependent endocytosis of surface AMPA receptors (AMPAR) as a first step to receptor recycling or degradation. However, it remains unknown whether receptor recycling influences AMPAR lateral diffusion and whether EZs are important for the expression of synaptic potentiation. Here, we demonstrate that the presence of both EZs and AMPAR recycling maintain a large pool of mobile AMPARs at synapses. In addition, we find that synaptic potentiation is accompanied by an accumulation and immobilization of AMPARs at synapses resulting from both their exocytosis and stabilization at the PSD. Displacement of EZs from the postsynaptic region impairs the expression of synaptic potentiation by blocking AMPAR recycling. Thus, receptor recycling is crucial for maintaining a mobile population of surface AMPARs that can be delivered to synapses for increases in synaptic strength.
dc.language.isoen
dc.publisherElsevier
dc.title.enEndocytic Trafficking and Recycling Maintain a Pool of Mobile Surface AMPA Receptors Required for Synaptic Potentiation
dc.typeArticle de revue
dc.identifier.doi10.1016/j.neuron.2009.05.025
bordeaux.journalNeuron
bordeaux.page92-105
bordeaux.volume63
bordeaux.issue1
bordeaux.peerReviewedoui
hal.identifierhal-00506434
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00506434v1
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