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Surface Mobility of Postsynaptic AMPARs Tunes Synaptic Transmission

hal.structure.identifierPhysiologie cellulaire de la synapse [PCS]
dc.contributor.authorHEINE, Martin
hal.structure.identifierPhysiologie cellulaire de la synapse [PCS]
dc.contributor.authorGROC, Laurent
hal.structure.identifierLeibniz-Institut für Neurobiologie [LIN]
dc.contributor.authorFRISCHKNECHT, Renato
hal.structure.identifierDepartment of Neuroscience
dc.contributor.authorBÉÏQUE, Jean-Claude
hal.structure.identifierCentre de physique moléculaire optique et hertzienne [CPMOH]
dc.contributor.authorCOGNET, Laurent
hal.structure.identifierCentre de physique moléculaire optique et hertzienne [CPMOH]
dc.contributor.authorLOUNIS, Brahim
hal.structure.identifierDepartment of Neuroscience
dc.contributor.authorRUMBAUGH, Gavin
hal.structure.identifierDepartment of Neuroscience
dc.contributor.authorHUGANIR, Richard L.
hal.structure.identifierPhysiologie cellulaire de la synapse [PCS]
dc.contributor.authorCHOQUET, Daniel
dc.date.issued2008-04-11
dc.identifier.issn0036-8075
dc.description.abstractEnAMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission. Upon fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from fast synaptic depression has been attributed solely to recovery of transmitter release and/or AMPAR desensitization. We show that AMPAR lateral diffusion, observed in both intact hippocampi and cultured neurons, allows fast exchange of desensitized receptors with naive functional ones within or near the postsynaptic density. Recovery from depression in the tens of millisecond time range can be explained in part by this fast receptor exchange. Preventing AMPAR surface movements through cross-linking, endogenous clustering, or calcium rise all slow recovery from depression. Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses.
dc.language.isoen
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.title.enSurface Mobility of Postsynaptic AMPARs Tunes Synaptic Transmission
dc.typeArticle de revue
dc.identifier.doi10.1126/science.1152089
bordeaux.journalScience
bordeaux.page201-205
bordeaux.volume320
bordeaux.issue5873
bordeaux.peerReviewedoui
hal.identifierhal-00747627
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00747627v1
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