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Intestinal Inflammation in Children with Cystic Fibrosis Is Associated with Crohn’s-Like Microbiota Disturbances

hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorENAUD, Raphaël
hal.structure.identifierCentre de Bioinformatique de Bordeaux [CBIB]
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
dc.contributor.authorHOOKS, Katarzyna
hal.structure.identifierCentre de Bioinformatique de Bordeaux [CBIB]
dc.contributor.authorBARRÉ, Aurélien
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorBARNETCHE, Thomas
hal.structure.identifierLaboratoire Hubert Curien [LabHC]
dc.contributor.authorHUBERT, Christophe
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorMASSOT, Marie
hal.structure.identifierUSC EA 3671, infections humaines à mycoplasmes et chlamydiae
dc.contributor.authorBAZIN, Thomas
dc.contributor.authorCLOUZEAU, Haude
hal.structure.identifierCentre de Ressources et de Compétences en Mucoviscidose [CHU Toulouse] [CRCM Toulouse]
dc.contributor.authorBUI, Stéphanie
hal.structure.identifierService de Pneumologie Pédiatrique [Bordeaux]
dc.contributor.authorFAYON, Michaël
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorBERGER, Patrick
hal.structure.identifierInfection à helicobacter, inflammation et cancer
dc.contributor.authorLEHOURS, Philippe
dc.contributor.authorBÉBÉAR, Cécile
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
hal.structure.identifierCentre de Bioinformatique de Bordeaux [CBIB]
dc.contributor.authorNIKOLSKI, Macha
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorLAMIREAU, Thierry
hal.structure.identifierService de Parasitologie-Mycologie [CHRU LIlle]
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDELHAES, Laurence
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorSCHAEVERBEKE, Thierry
dc.date.issued2019
dc.identifier.issn2077-0383
dc.description.abstractEnCystic fibrosis (CF) is a systemic genetic disease that leads to pulmonary and digestive disorders. In the majority of CF patients, the intestine is the site of chronic inflammation and microbiota disturbances. The link between gut inflammation and microbiota dysbiosis is still poorly understood. The main objective of this study was to assess gut microbiota composition in CF children depending on their intestinal inflammation. We collected fecal samples from 20 children with CF. Fecal calprotectin levels were measured and fecal microbiota was analyzed by 16S rRNA sequencing. We observed intestinal inflammation was associated with microbiota disturbances characterized mainly by increased abundances of Staphylococcus, Streptococcus, and Veillonella dispar, along with decreased abundances of Bacteroides, Bifidobacterium adolescentis, and Faecalibacterium prausnitzii. Those changes exhibited similarities with that of Crohn's disease (CD), as evidenced by the elevated CD Microbial-Dysbiosis index that we applied for the first time in CF. Furthermore, the significant over-representation of Streptococcus in children with intestinal inflammation appears to be specific to CF and raises the issue of gut-lung axis involvement. Taken together, our results provide new arguments to link gut microbiota and intestinal inflammation in CF and suggest the key role of the gut-lung axis in the CF evolution.
dc.description.sponsorshipInitiative d'excellence de l'Université de Bordeaux
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.endysbiosis index
dc.subject.encystic fibrosis
dc.subject.enfecal calprotectin
dc.subject.engut microbiota
dc.subject.enintestinal inflammation
dc.title.enIntestinal Inflammation in Children with Cystic Fibrosis Is Associated with Crohn’s-Like Microbiota Disturbances
dc.typeArticle de revue
dc.identifier.doi10.3390/jcm8050645
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Hépatologie et Gastroentérologie
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Pédiatrie
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie
bordeaux.journalJournal of Clinical Medicine
bordeaux.page645
bordeaux.volume8
bordeaux.issue5
bordeaux.peerReviewedoui
hal.identifierhal-02126914
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02126914v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Clinical%20Medicine&rft.date=2019&rft.volume=8&rft.issue=5&rft.spage=645&rft.epage=645&rft.eissn=2077-0383&rft.issn=2077-0383&rft.au=ENAUD,%20Rapha%C3%ABl&HOOKS,%20Katarzyna&BARR%C3%89,%20Aur%C3%A9lien&BARNETCHE,%20Thomas&HUBERT,%20Christophe&rft.genre=article


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