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The rate and potential relevance of new mutations in a colonizing plant lineage

hal.structure.identifierMax-Planck-Institut
dc.contributor.authorEXPOSITO-ALONSO, Moises
hal.structure.identifierMax-Planck-Institut
dc.contributor.authorBECKER, Claude
hal.structure.identifierEberhard Karls Universität Tübingen = University of Tübingen
dc.contributor.authorSCHUENEMANN, Verena J.
hal.structure.identifierEberhard Karls Universität Tübingen = University of Tübingen
dc.contributor.authorREITER, Ella
hal.structure.identifierGregor Mendel Institute of Molecular Plant Biology [GMI]
dc.contributor.authorSETZER, Claudia
hal.structure.identifierGregor Mendel Institute of Molecular Plant Biology [GMI]
dc.contributor.authorSLOVAK, Radka
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorBRACHI, Benjamin
hal.structure.identifierMax-Planck-Institut
dc.contributor.authorHAGMANN, Jörg
hal.structure.identifierMax-Planck-Institut
dc.contributor.authorGRIMM, Dominik G.
hal.structure.identifierChinese Academy of Sciences [CAS]
hal.structure.identifierDepartment of Ecology and Evolution [Chicago]
dc.contributor.authorCHEN, Jiahui
hal.structure.identifierGregor Mendel Institute of Molecular Plant Biology [GMI]
dc.contributor.authorBUSCH, Wolfgang
hal.structure.identifierDepartment of Ecology and Evolution [Chicago]
dc.contributor.authorBERGELSON, Joy
hal.structure.identifierDepartment of Biology
dc.contributor.authorNESS, Rob W.
hal.structure.identifierEberhard Karls Universität Tübingen = University of Tübingen
dc.contributor.authorKRAUSE, Johannes
hal.structure.identifierMax-Planck-Institut
dc.contributor.authorBURBANO, Hernan A.
hal.structure.identifierMax-Planck-Institut
dc.contributor.authorWEIGEL, Detlef
dc.date.issued2018
dc.identifier.issn1553-7390
dc.description.abstractEnBy following the evolution of populations that are initially genetically homogeneous, much can be learned about core biological principles. For example, it allows for detailed studies of the rate of emergence of de novo mutations and their change in frequency due to drift and selection. Unfortunately, in multicellular organisms with generation times of months or years, it is difficult to set up and carry out such experiments over many generations. An alternative is provided by "natural evolution experiments" that started from colonizations or invasions of new habitats by selfing lineages. With limited or missing gene flow from other lineages, new mutations and their effects can be easily detected. North America has been colonized in historic times by the plant Arabidopsis thaliana, and although multiple inter-crossing lineages are found today, many of the individuals belong to a single lineage, HPG1. To determine in this lineage the rate of substitutions-the subset of mutations that survived natural selection and drift-, we have sequenced genomes from plants collected between 1863 and 2006. We identified 73 modern and 27 herbarium specimens that belonged to HPG1. Using the estimated substitution rate, we infer that the last common HPG1 ancestor lived in the early 17 th century, when it was most likely introduced by chance from Europe. Mutations in coding regions are depleted in frequency compared to those in other portions of the genome, consistent with purifying selection. Nevertheless, a handful of mutations is found at high frequency in present-day populations. We link these to detectable phenotypic variance in traits of known ecological importance, life history and growth, which could reflect their adaptive value. Our work showcases how, by applying genomics methods to a combination of modern and historic samples from colonizing lineages, we can directly study new mutations and their potential evolutionary relevance.
dc.language.isoen
dc.publisherPublic Library of Science
dc.title.enThe rate and potential relevance of new mutations in a colonizing plant lineage
dc.typeArticle de revue
dc.identifier.doi10.1371/journal.pgen.1007155
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalPLoS Genetics
bordeaux.page1-21
bordeaux.volume14
bordeaux.issue2
bordeaux.peerReviewedoui
hal.identifierhal-02625418
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02625418v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS%20Genetics&rft.date=2018&rft.volume=14&rft.issue=2&rft.spage=1-21&rft.epage=1-21&rft.eissn=1553-7390&rft.issn=1553-7390&rft.au=EXPOSITO-ALONSO,%20Moises&BECKER,%20Claude&SCHUENEMANN,%20Verena%20J.&REITER,%20Ella&SETZER,%20Claudia&rft.genre=article


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