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RTM3, which controls long distance movement of potyviruses, is a member of a new plant gene family encoding a meprin and TRAF homology (MATH) domain-containing protein

hal.structure.identifierGénomique, développement et pouvoir pathogène [GD2P]
dc.contributor.authorCOSSON, Patrick
hal.structure.identifierGénomique, développement et pouvoir pathogène [GD2P]
dc.contributor.authorSOFER, Luc
hal.structure.identifierGénomique, développement et pouvoir pathogène [GD2P]
dc.contributor.authorLE, Quang Hien
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorLEGER, Valérie
hal.structure.identifierGénomique, développement et pouvoir pathogène [GD2P]
dc.contributor.authorSCHURDI-LEVRAUD, Valerie
hal.structure.identifierCenter for Genome Research and Biocomputing
dc.contributor.authorWHITHAM, Steven A.
hal.structure.identifierCenter for Genome Research and Biocomputing
dc.contributor.authorYAMAMOTO, Miki L.
hal.structure.identifierCenter for Genome Research and Biocomputing
dc.contributor.authorGOPALAN, Suresh
hal.structure.identifierGénomique, développement et pouvoir pathogène [GD2P]
dc.contributor.authorLE GALL, Olivier
hal.structure.identifierGénomique, développement et pouvoir pathogène [GD2P]
dc.contributor.authorCANDRESSE, Thierry
hal.structure.identifierCenter for Genome Research and Biocomputing
dc.contributor.authorCARRINGTON, James C.
hal.structure.identifierGénomique, développement et pouvoir pathogène [GD2P]
dc.contributor.authorREVERS, Frederic
dc.date.issued2010
dc.identifier.issn0032-0889
dc.description.abstractEnRestriction of long-distance movement of several potyviruses in Arabidopsis (Arabidopsis thaliana) is controlled by at least three dominant restricted TEV movement (RTM) genes, named RTM1, RTM2, and RTM3. RTM1 encodes a protein belonging to the jacalin family, and RTM2 encodes a protein that has similarities to small heat shock proteins. In this article, we describe the positional cloning of RTM3, which encodes a protein belonging to an undescribed protein family of 29 members that has a meprin and TRAF homology (MATH) domain in its amino-terminal region and a coiled-coil domain at its carboxy-terminal end. Involvement in the RTM resistance system is the first biological function experimentally identified for a member of this new gene family in plants. Our analyses showed that the coiled-coil domain is not only highly conserved between RTM3-homologous MATH-containing proteins but also in proteins lacking a MATH domain. The cluster organization of the RTM3 homologs in the Arabidopsis genome suggests the role of duplication events in shaping the evolutionary history of this gene family, including the possibility of deletion or duplication of one or the other domain. Protein-protein interaction experiments revealed RTM3 self-interaction as well as an RTM1-RTM3 interaction. However, no interaction has been detected involving RTM2 or the potyviral coat protein previously shown to be the determinant necessary to overcome the RTM resistance. Taken together, these observations strongly suggest the RTM proteins might form a multiprotein complex in the resistance mechanism to block the long-distance movement of potyviruses.
dc.language.isoen
dc.publisherOxford University Press ; American Society of Plant Biologists
dc.subject.enrtm3
dc.title.enRTM3, which controls long distance movement of potyviruses, is a member of a new plant gene family encoding a meprin and TRAF homology (MATH) domain-containing protein
dc.typeArticle de revue
dc.identifier.doi10.1104/pp.110.155754
dc.subject.halSciences du Vivant [q-bio]/Génétique/Génétique des plantes
bordeaux.journalPlant Physiology
bordeaux.page222-232
bordeaux.volume154
bordeaux.issue1
bordeaux.peerReviewedoui
hal.identifierhal-02664029
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02664029v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Plant%20Physiology&rft.date=2010&rft.volume=154&rft.issue=1&rft.spage=222-232&rft.epage=222-232&rft.eissn=0032-0889&rft.issn=0032-0889&rft.au=COSSON,%20Patrick&SOFER,%20Luc&LE,%20Quang%20Hien&LEGER,%20Val%C3%A9rie&SCHURDI-LEVRAUD,%20Valerie&rft.genre=article


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