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Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: synthesis, physicochemical characterization, and in vitro experiments

hal.structure.identifierPhysico-chimie, pharmacotechnie, biopharmacie [PCPB]
hal.structure.identifierDipartimento Farmaceutico
dc.contributor.authorSONVICO, Fabio
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMORNET, Stéphane
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorVASSEUR, Sébastien
hal.structure.identifierPhysico-chimie, pharmacotechnie, biopharmacie [PCPB]
dc.contributor.authorDUBERNET, Catherine
hal.structure.identifierDéveloppement et évolution [DE]
dc.contributor.authorJAILLARD, Danielle
hal.structure.identifierDéveloppement et évolution [DE]
dc.contributor.authorDEGROUARD, Jeril
hal.structure.identifierImmunologie et chimie thérapeutiques [ICT]
dc.contributor.authorHOEBEKE, Johan
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDUGUET, Etienne
hal.structure.identifierDipartimento Farmaceutico
dc.contributor.authorCOLOMBO, Paolo
hal.structure.identifierPhysico-chimie, pharmacotechnie, biopharmacie [PCPB]
dc.contributor.authorCOUVREUR, Patrick
dc.date.issued2005
dc.identifier.issn1043-1802
dc.description.abstractEnNew folate-conjugated superparamagnetic maghemite nanoparticles have been synthesized for the intracellular hyperthermia treatment of solid tumors. These ultradispersed nanosystems have been characterized for their physicochemical properties and tumor cell targeting ability, facilitated by surface modification with folic acid. Preliminary experiments of nanoparticles heating under the influence of an alternating magnetic field at 108 kHz have been also performed. The nanoparticle size, surface charge, and colloidal stability have been assessed in various conditions of ionic strength and pH. The ability of these folate "decorated" maghemite nanoparticles to recognize the folate receptor has been investigated both by surface plasmon resonance and in folate receptor expressing cell lines, using radiolabeled folic acid in competitive binding experiments. The specificity of nanoparticle cellular uptake has been further investigated by transmission electron microscopy after incubation of these nanoparticles in the presence of three cell lines with differing folate receptor expression levels. Qualitative and quantitative determinations of both folate nanoparticles and nontargeted control nanoparticles demonstrated a specific cell internalization of the folate superparamagnetic nanoparticles.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enIntracellular hyperthermia
dc.subject.enDelivery drugs
dc.subject.enTherapy
dc.subject.enCells
dc.subject.enLiposomes
dc.subject.enEndocytosis
dc.subject.enDiagnosis
dc.subject.enCarriers
dc.subject.enReceptor
dc.subject.enDextran
dc.title.enFolate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: synthesis, physicochemical characterization, and in vitro experiments
dc.typeArticle de revue
dc.identifier.doi10.1021/bc050050z
dc.subject.halChimie/Matériaux
bordeaux.journalBioconjugate Chemistry
bordeaux.pagep. 1181-1188
bordeaux.volumevol. 16, n° 5
bordeaux.peerReviewedoui
hal.identifierhal-00102165
hal.version1
hal.popularnon
hal.audienceNon spécifiée
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00102165v1
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