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Thermo-responsive gold/poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) core-corona nanoparticles as a drug delivery system
hal.structure.identifier | Centre d'Etude et de Recherche sur les Macromolécules [CERM] | |
hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
dc.contributor.author | LIU, Ji | |
hal.structure.identifier | Centre d'Etude et de Recherche sur les Macromolécules [CERM] | |
dc.contributor.author | DETREMBLEUR, Christophe | |
hal.structure.identifier | Centre d'Etude et de Recherche sur les Macromolécules [CERM] | |
dc.contributor.author | HURTGEN, Marie | |
hal.structure.identifier | Centre d'Etude et de Recherche sur les Macromolécules [CERM] | |
dc.contributor.author | DEBUIGNE, Antoine | |
hal.structure.identifier | Laboratory of Mammalian Cell Culture [GIGA-R] | |
dc.contributor.author | DE PAUW-GILLET, Marie-Claire | |
hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
dc.contributor.author | MORNET, Stéphane | |
hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
dc.contributor.author | DUGUET, Etienne | |
hal.structure.identifier | Centre d'Etude et de Recherche sur les Macromolécules [CERM] | |
dc.contributor.author | JÉRÔME, Christine | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1759-9954 | |
dc.description.abstractEn | Core-corona gold/poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) nanoparticles (gold@PVOH-b-PNVCL NPs) were fabricated via an in situ method, where a gold salt was reduced within the macromolecular aqueous solution. Arrangement of macromolecular chains on the surface of gold cores was studied by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy and infrared spectroscopy. The responsiveness to temperature and the preserved colloidal stability of the gold@PVOH-b-PNVCL NPs above the lower critical solution temperature (LCST) were confirmed by dynamic light scattering and turbidity measurements. The drug loading capacity (DLC of ca. 1.3-2.8 wt%) of the gold@PVOH-b-PNVCL NPs as a drug delivery system (DDS) was tested with Nadolol®, a hydrophilic drug, and the release behaviours were studied at several temperatures. PVOH-b-PNVCL copolymers with an LCST of a few degrees above the biological temperature (37 °C), for example, PVOH180-b-PNVCL110 (LCST of 41 °C), are preferential, due to the slower release at 37 °C, but a faster release at temperatures that are a few degrees higher. The cytocompatibility of the gold@PVOH-b-PNVCL NPs against mouse fibroblastic L929 cells was evaluated via the MTS assay. Cellular uptake within MEL-5 human melanoma cells was studied by confocal laser scanning microscopy, fluorescence-activated cell sorting and TEM techniques and it showed that gold@PVOH-b-PNVCL NPs preferably accumulated within the cellular cytoplasm, with an incubation concentration and period-dependent uptake process. All these results corroborated a general utility of these thermo-responsive gold@PVOH-b-PNVCL NPs for drug delivery and controlled drug release. | |
dc.language.iso | en | |
dc.publisher | Royal Society of Chemistry - RSC | |
dc.title.en | Thermo-responsive gold/poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) core-corona nanoparticles as a drug delivery system | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1039/c4py00352g | |
dc.subject.hal | Chimie/Matériaux | |
bordeaux.journal | Polymer Chemistry | |
bordeaux.page | 5289-5299 | |
bordeaux.volume | 5 | |
bordeaux.issue | 18 | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01059137 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01059137v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Polymer%20Chemistry&rft.date=2014&rft.volume=5&rft.issue=18&rft.spage=5289-5299&rft.epage=5289-5299&rft.eissn=1759-9954&rft.issn=1759-9954&rft.au=LIU,%20Ji&DETREMBLEUR,%20Christophe&HURTGEN,%20Marie&DEBUIGNE,%20Antoine&DE%20PAUW-GILLET,%20Marie-Claire&rft.genre=article |
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