Crystal structure of N-(7-{[2-(dimethylamino)ethyl]amino}-1-methyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-3,4,5-trimethoxybenzamide
| hal.structure.identifier | Régulations Naturelles et Artificielles [ARNA] | |
| dc.contributor.author | GUILLON, Jean | |
| hal.structure.identifier | Cibles et Médicaments des Infections et de l'Immunité - EA 1155 [IICiMed] | |
| dc.contributor.author | MONTOIR, David | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | MARCHIVIE, Mathieu | |
| hal.structure.identifier | Cibles et Médicaments des Infections et de l'Immunité - EA 1155 [IICiMed] | |
| dc.contributor.author | DUFLOS, Muriel | |
| hal.structure.identifier | Cibles et Médicaments des Infections et de l'Immunité - EA 1155 [IICiMed] | |
| dc.contributor.author | BAZIN, Marc-Antoine | |
| dc.date.issued | 2017 | |
| dc.description.abstractEn | The X-ray crystal structure of N-(7-{[2-(dimethylamino)ethyl]amino}-1-methyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-3,4,5-trimethoxybenzamide, a potential anticancer agent targeting Hsp90, was established. It crystallizes in the triclinic space group P-1 with cell parameters a = 9.3554(4)Å, b = 11.4450(5)Å, c = 11.5629(4)Å, α = 87.140(2), β = 78.8070(19), γ = 69.2119(19), V = 1135.21(8)Å3 and Z = 2. The crystal structure was refined to final values of R1 = 0.0492 and wR2 = 0.1386. An X-ray crystal structure analysis revealed that each molecule features intermolecular N–H···N hydrogen bonds to form dimers. | |
| dc.language.iso | en | |
| dc.publisher | Japan Society for Analytical Chemistry's | |
| dc.title.en | Crystal structure of N-(7-{[2-(dimethylamino)ethyl]amino}-1-methyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-3,4,5-trimethoxybenzamide | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.2116/xraystruct.33.41 | |
| dc.subject.hal | Chimie/Matériaux | |
| bordeaux.journal | X-Ray Structure Analysis Online | |
| bordeaux.page | 41-43 | |
| bordeaux.volume | 33 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01612261 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01612261v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=X-Ray%20Structure%20Analysis%20Online&rft.date=2017&rft.volume=33&rft.spage=41-43&rft.epage=41-43&rft.au=GUILLON,%20Jean&MONTOIR,%20David&MARCHIVIE,%20Mathieu&DUFLOS,%20Muriel&BAZIN,%20Marc-Antoine&rft.genre=article |
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