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Effects of high hydrostatic pressure on several sensitive therapeutic molecules and a soft nanodispersed drug delivery system.

hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorRIGALDIE, Yohan
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorLARGETEAU, Alain
hal.structure.identifierEllipse Pharmaceutical
dc.contributor.authorLEMAGNEN, Gilles
hal.structure.identifierInstitut du Pin
dc.contributor.authorIBALOT, Fabienne
hal.structure.identifierInstitut du Pin
dc.contributor.authorPARDON, Patrick
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDEMAZEAU, Gérard
hal.structure.identifierEllipse Pharmaceutical
dc.contributor.authorGRISLAIN, Luc
dc.date.issued2003
dc.identifier.issn0724-8741
dc.description.abstractEnPURPOSE: According to the development in the last decade of industrial processes using high hydrostatic pressure (HHP) for preservation of several commercial food products, novel sterilization or decontamination processes for pharmaceutical products could be conceivable. The aim of this work is to evaluate the effects of HHP on the integrity of insulin and heparin solutions, suspension of monoclonal antibodies and Spherulites. METHODS: High performance liquid chromatography, thin layer chromatography, capillary electrophoresis assays, ELISA tests, laser granulometry and spectrophotometry analyses have been performed to compare HHP treated drugs (in a domain of pressure and temperature ranging respectively from 20 up to 500 MPa and from 20 degrees C up to 37 degrees C) vs. untreated ones. RESULTS: No difference has been detected except for monoclonal antibodies that are altered above 500 MPa. CONCLUSIONS: The structure integrity of sensitive molecule due to the small energy involved by HHP and the development of industrial plants (intended for the decontamination of food products) confer to this technology the potential of a new method for sterilization of fragile drugs and an original alternative to aseptic processes and sterilizing filtration.
dc.language.isoen
dc.publisherAmerican Association of Pharmaceutical Scientists
dc.subject.meshAntibodies, Monoclonal
dc.subject.meshChromatography, High Pressure Liquid
dc.subject.meshDrug Compounding
dc.subject.meshDrug Delivery Systems
dc.subject.meshElectrophoresis, Capillary
dc.subject.meshEnzyme-Linked Immunosorbent Assay
dc.subject.meshHardness
dc.subject.meshHeparin
dc.subject.meshHydrostatic Pressure
dc.subject.meshInsulin
dc.subject.meshParticle Size
dc.subject.meshPeptides
dc.subject.meshPharmaceutical Preparations
dc.subject.meshSolutions
dc.subject.meshSuspensions
dc.subject.meshTemperature
dc.subject.meshChromatography, Thin Layer
dc.title.enEffects of high hydrostatic pressure on several sensitive therapeutic molecules and a soft nanodispersed drug delivery system.
dc.typeArticle de revue
dc.identifier.doi10.1023/B:PHAM.0000008054.80136.5a
dc.subject.halChimie/Matériaux
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques
bordeaux.journalPharmaceutical Research
bordeaux.page2036-2040
bordeaux.volume20
bordeaux.issue12
bordeaux.peerReviewedoui
hal.identifierhal-00170011
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00170011v1
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