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Development and characterization of a PLGA-HA composite material to fabricate 3D-printed scaffolds for bone tissue engineering

hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBABILOTTE, Joanna
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorMARTIN, Benoit
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorGUDURIC, Vera
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBAREILLE, Reine
hal.structure.identifierEquipe de recherche sur les relations matrice extracellulaire-cellules [ERRMECe]
dc.contributor.authorAGNIEL, Rémy
hal.structure.identifierCIC Bordeaux
dc.contributor.authorROQUES, Samantha
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 1 LCPO : Polymerization Catalyses & Engineering
dc.contributor.authorHÉROGUEZ, Valérie
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorDUSSAUZE, Marc
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorGAUDON, Manuel
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorLE NIHOUANNEN, Damien
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierCHU Bordeaux
dc.contributor.authorCATROS, Sylvain
dc.date.issued2021-01
dc.identifier.issn0928-4931
dc.description.abstractEnAdditive manufacturing is a rising field in bone tissue engineering. Additive fabrication offers reproducibility, high precision and rapid manufacture of custom patient-specific scaffolds. The development of appropriate composite materials for biomedical applications is critical to reach clinical application of these novel biomaterials. In this work, medical grade poly(lactic-co-glycolic) acid (PLGA) was mixed with hydroxyapatite nanoparticles (nHA) to fabricate 3D porous scaffolds by Fused Deposition Modeling. We have first confirmed that the composite material could be printed in a reproductive manner. Physical characterization demonstrated a low degradation of the material during manufacturing steps and an expected loading and homogeneous distribution of nHA. In vitro biodegradation of the scaffolds showed modifications of morphological and physicochemical properties over time. The composite scaffolds were biocompatible and high cell viability was observed in vitro, as well as a maintain of cell proliferation. As expected, the addition of nHA displayed a positive impact on osteodifferentiation in vitro. Furthermore, a limited inflammatory reaction was observed after subcutaneous implantation of the materials in the rat. Overall, this study suggests that this composite material is suitable for bone tissue engineering applications.
dc.description.sponsorshipFabrication d'un substitut osseux pour la chirurgie orale par assemblage multi-couches de membranes cellularisées - ANR-16-CE18-0009
dc.language.isoen
dc.publisherElsevier
dc.subject.enComposite
dc.subject.enPolymer
dc.subject.enHydroxyapatite
dc.title.enDevelopment and characterization of a PLGA-HA composite material to fabricate 3D-printed scaffolds for bone tissue engineering
dc.typeArticle de revue
dc.identifier.doi10.1016/j.msec.2020.111334
dc.subject.halChimie/Matériaux
bordeaux.journalMaterials Science and Engineering: C
bordeaux.page111334 (13 p.)
bordeaux.volume118
bordeaux.peerReviewedoui
hal.identifierhal-02930819
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02930819v1
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