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hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
dc.contributor.authorAQIL, Abdelatif
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorVASSEUR, Sébastien
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDUGUET, Etienne
hal.structure.identifierIngénierie de la vectorisation particulaire
dc.contributor.authorPASSIRANI, Catherine
hal.structure.identifierIngénierie de la vectorisation particulaire
dc.contributor.authorBENOÎT, Jean-Pierre
hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
dc.contributor.authorJÉRÔME, Robert
hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
dc.contributor.authorJÉRÔME, Christine
dc.date.issued2008
dc.identifier.issn0959-9428
dc.description.abstractEnVarious temperature-responsive N-isopropylacrylamide-based functional copolymers were prepared and used for the stabilization of iron oxide nanoparticles. The copolymers investigated are poly(acrylic acid)-b-poly(N-isopropylacrylamide) (PAA-PNIPAM) and poly(acrylic acid)-b-poly(N-isopropylacrylamide)-b-poly(acrylate methoxy poly(ethylene oxide)) (PAA-PNIPAM-PAMPEO), with different molecular weights. The coated nanoparticles were characterized in terms of size by a combination of dynamic light scattering (DLS) and transmission electron microscopy (TEM). A sharp temperature transition was confirmed by particle size measurements vs. temperature. In addition, the stealthiness of the coated nanoparticles has been assessed in vitro by the haemolytic CH50 test. These measurements evidenced the crucial role of the PEO segments on the stealthiness of the nanoparticles and thus that such copolymers are particularly suitable for biomedical applications. Preliminary experiments of alternating magnetic field induced heating were performed and specific absorption rates of the various samples were recorded.
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.subject.enCopolymer
dc.subject.enMagnetism
dc.subject.enNanoparticles
dc.subject.enHyperthermia
dc.title.enMagnetic nanoparticles coated by temperature responsive copolymers for hyperthermia
dc.typeArticle de revue
dc.identifier.doi10.1039/b804003f
dc.subject.halChimie/Matériaux
bordeaux.journalJournal of Materials Chemistry
bordeaux.page3352-3360
bordeaux.volume18
bordeaux.issue28
bordeaux.peerReviewedoui
hal.identifierhal-00295171
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00295171v1
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