1-phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: synthesis, crystal structure and anti-leukemic activity
| hal.structure.identifier | Acides Nucléiques : Régulations Naturelle et Artificielle [ARNA] | |
| dc.contributor.author | GUILLON, Jean | |
| hal.structure.identifier | Acides Nucléiques : Régulations Naturelle et Artificielle [ARNA] | |
| dc.contributor.author | SAVRIMOUTOU, Solène | |
| hal.structure.identifier | Acides Nucléiques : Régulations Naturelle et Artificielle [ARNA] | |
| dc.contributor.author | RUBIO, Sandra | |
| hal.structure.identifier | Acides Nucléiques : Régulations Naturelle et Artificielle [ARNA] | |
| dc.contributor.author | MOREAU, Stéphane | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | PINAUD, Noël | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | MARCHIVIE, Mathieu | |
| hal.structure.identifier | Biothérapies des maladies génétiques et cancers | |
| dc.contributor.author | DESPLAT, Vanessa | |
| dc.date.issued | 2020 | |
| dc.identifier.issn | 1422-8599 | |
| dc.description.abstractEn | 1-Phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one has been successfully synthesized via a multi-step pathway starting from 2-nitroaniline. Structure characterization of this original pyrrolo[1,2-a]quinoxaline derivative was achieved by FT-IR, 1H-NMR, 13C-NMR, X-Ray and HRMS spectral analysis. This title compound shows interesting cytotoxic potential against several human leukemia cell lines (K562, HL60, and U937 cells). | |
| dc.language.iso | en | |
| dc.publisher | MDPI | |
| dc.subject.en | pyrrolo[1 2-a]quinoxaline derivative | |
| dc.subject.en | leukemia | |
| dc.subject.en | antiproliferative activity | |
| dc.title.en | 1-phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: synthesis, crystal structure and anti-leukemic activity | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.3390/M1113 | |
| dc.subject.hal | Chimie/Chimie thérapeutique | |
| dc.subject.hal | Chimie/Cristallographie | |
| bordeaux.journal | Molbank | |
| bordeaux.page | M1113 | |
| bordeaux.volume | 2020 | |
| bordeaux.issue | 1 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-02986229 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-02986229v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molbank&rft.date=2020&rft.volume=2020&rft.issue=1&rft.spage=M1113&rft.epage=M1113&rft.eissn=1422-8599&rft.issn=1422-8599&rft.au=GUILLON,%20Jean&SAVRIMOUTOU,%20Sol%C3%A8ne&RUBIO,%20Sandra&MOREAU,%20St%C3%A9phane&PINAUD,%20No%C3%ABl&rft.genre=article |
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