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1-phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: synthesis, crystal structure and anti-leukemic activity

hal.structure.identifierAcides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
dc.contributor.authorGUILLON, Jean
hal.structure.identifierAcides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
dc.contributor.authorSAVRIMOUTOU, Solène
hal.structure.identifierAcides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
dc.contributor.authorRUBIO, Sandra
hal.structure.identifierAcides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
dc.contributor.authorMOREAU, Stéphane
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorPINAUD, Noël
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMARCHIVIE, Mathieu
hal.structure.identifierBiothérapies des maladies génétiques et cancers
dc.contributor.authorDESPLAT, Vanessa
dc.date.issued2020
dc.identifier.issn1422-8599
dc.description.abstractEn1-Phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one has been successfully synthesized via a multi-step pathway starting from 2-nitroaniline. Structure characterization of this original pyrrolo[1,2-a]quinoxaline derivative was achieved by FT-IR, 1H-NMR, 13C-NMR, X-Ray and HRMS spectral analysis. This title compound shows interesting cytotoxic potential against several human leukemia cell lines (K562, HL60, and U937 cells).
dc.language.isoen
dc.publisherMDPI
dc.subject.enpyrrolo[1 2-a]quinoxaline derivative
dc.subject.enleukemia
dc.subject.enantiproliferative activity
dc.title.en1-phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: synthesis, crystal structure and anti-leukemic activity
dc.typeArticle de revue
dc.identifier.doi10.3390/M1113
dc.subject.halChimie/Chimie thérapeutique
dc.subject.halChimie/Cristallographie
bordeaux.journalMolbank
bordeaux.pageM1113
bordeaux.volume2020
bordeaux.issue1
bordeaux.peerReviewedoui
hal.identifierhal-02986229
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02986229v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molbank&rft.date=2020&rft.volume=2020&rft.issue=1&rft.spage=M1113&rft.epage=M1113&rft.eissn=1422-8599&rft.issn=1422-8599&rft.au=GUILLON,%20Jean&SAVRIMOUTOU,%20Sol%C3%A8ne&RUBIO,%20Sandra&MOREAU,%20St%C3%A9phane&PINAUD,%20No%C3%ABl&rft.genre=article


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