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hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorARINI, Adeline
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorPIERRON, Fabien
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMORNET, Stéphane
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBAUDRIMONT, Magalie
dc.date.issued2020
dc.identifier.issn0944-1344
dc.description.abstractEnGold nanoparticles (AuNPs) are being developed and produced for a wide variety of industrial and biomedical applications, which raises the concern about their release and potential effects in the environment. In this study, we aim to assess the effects of PEGylated AuNPs and ionic gold on the freshwater bivalve Corbicula fluminea. As NP bioavailability is conditioned by many factors of variability, we focused on the determination of biodynamic parameters which control AuNP uptake and elimination in bivalves. Three experiments were conducted: (1) a waterborne exposure (0–24 mg/L for AuNPs and 0–12 mg/L for ionic gold), (2) a dietborne exposure (0–48 mg/L for AuNPs and 0–24 mg/L for ionic gold), and (3) an elimination phase (after waterborne exposure to 12 mg/L for AuNPs and 24 mg/L for ionic gold), to calculate rate constants for uptake from water(kuw), from food (kuf), and for the physiological elimination (ke) for AuNPs and AuCl(OH)3−. Jointly, the relative expression of several genes was investigated in the hemolymph cells to relate AuNPs and gold ion exposures to detoxification, oxidative stress, immune, and apoptosis responses in C. fluminea. Results show that kuw and kuf were around 10 and 30 times higher for AuNPs compared to AuCl(OH)3−, respectively. The ke was also faster in clams exposed to AuNPs meaning that they also had greater excretion capacities in comparison to gold ions. Water seems to be the main exposure pathway for C. fluminea according to kuw and kuf values for AuNPs and AuCl(OH)3− (kuw = 0.28 and 0.03, kuf = 0.009 and 0.001, respectively). The gene analyses pointed out important responses against oxidative stress, strong activations of genes of the immunity, and apoptosis after the waterborne exposure to AuNPs and to a lesser extent after exposure to gold ions. Very few responses were observed after the dietary exposure to both forms of gold, probably due to valve closure in response to contamination. While some studies suggest that the toxicity of nanoparticles may come from the release of metal ions, our results showed that the AuNPs we used were very stable (less than 1% of ion release) and generated more effects at the gene level than ionic gold. Therefore these results highlight the strong potential of toxicity of AuNPs compared to ionic gold and raise new concerns about the toxicity inherent to NPs in the environment.
dc.description.sponsorshipApproches à différentes échelles pour caractériser les interactions cellulaires, le transfert trophique et les impacts toxiques de nanoparticules métalliques chez les organismes aquatiques
dc.description.sponsorshipInitiative d'excellence de l'Université de Bordeaux
dc.language.isoen
dc.publisherSpringer Verlag
dc.subject.enBivalves
dc.subject.enCorbicula fluminea
dc.subject.enRate constants
dc.subject.enGold nanoparticles
dc.subject.enToxicity
dc.subject.enBiodynamic
dc.subject.enGene expression
dc.title.enBioaccumulation dynamics and gene regulation in a freshwater bivalve after aqueous and dietary exposures to gold nanoparticles and ionic gold
dc.typeArticle de revue
dc.identifier.doi10.1007/s11356-018-4009-4
dc.subject.halChimie/Matériaux
bordeaux.journalEnvironmental Science and Pollution Research
bordeaux.page3637-3650
bordeaux.volume27
bordeaux.issue4
bordeaux.peerReviewedoui
hal.identifierhal-02294343
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02294343v1
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