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Design of polypeptide-functionalized polystyrene microspheres

hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
dc.contributor.authorBOUSQUET, Antoine
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
dc.contributor.authorPERRIER-CORNET, Romain
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
dc.contributor.authorIBARBOURE, Emmanuel
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
hal.structure.identifierTeam 1 LCPO : Polymerization Catalyses & Engineering
dc.contributor.authorPAPON, Eric
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorLABRUGÈRE, Christine
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
hal.structure.identifierTeam 1 LCPO : Polymerization Catalyses & Engineering
dc.contributor.authorHÉROGUEZ, Valérie
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
dc.contributor.authorRODRIGUEZ-HERNANDEZ, Juan
dc.date.issued2008
dc.identifier.issn1525-7797
dc.description.abstractEnIn this contribution, the principle of spontaneous surface segregation has been applied for the preparation of polypeptide-functionalized polystyrene microspheres. For that purpose, an amphiphilic diblock copolymer was introduced in the mixture styrene/divinylbenzene and polymerized using AIBN as initiator. During the polymerization, cross-linked particles were obtained in which the diblock copolymer was encapsulated. The amphiphilic diblock copolymers used throughout this study contain a hydrophilic polypeptide segment, either poly(L-lysine) or poly(L-glutamic acid) and a hydrophobic polystyrene block. After 4 h of polymerization, rather monodisperse particles with sizes of ∼3-4 μm were obtained. Upon annealing in hot water, the hydrophilic polypeptides migrate to the interface, hence, either positively charged or neutral particles were obtained when poly(L-lysine) is revealed at the surface and exposed to acidic or basic pH, respectively. On the opposite, negatively charged particles were achieved in basic pH water by using poly(L-glutamic acid) as additive. The surface chemical composition was modified by changing the environment of the particles. Thus, exposure in toluene provoked a surface rearrangement, and due to its affinity, the polystyrene block reorients toward the interface.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enPolystyrene
dc.subject.enFunctionalized materials
dc.subject.enMicrospheres
dc.subject.enLATEX-PARTICLES
dc.subject.enPRECIPITATION POLYMERIZATION
dc.subject.enDIVINYL BENZENE) MICROSPHERES
dc.subject.enTRANSFER RADICAL POLYMERIZATION
dc.subject.enPOLY(L-LYSINE)
dc.subject.enMETHACRYLATE
dc.subject.enTRANSITION
dc.subject.enMORPHOLOGY
dc.subject.enBLOCK-COPOLYMERS
dc.subject.enNANOPARTICLES
dc.title.enDesign of polypeptide-functionalized polystyrene microspheres
dc.typeArticle de revue
dc.identifier.doi10.1021/bm8000292
dc.subject.halChimie/Matériaux
dc.subject.halChimie/Polymères
bordeaux.journalBiomacromolecules
bordeaux.page1811-1817
bordeaux.volume9
bordeaux.issue7
bordeaux.peerReviewedoui
hal.identifierhal-00322870
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00322870v1
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