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Impact of gold nanoparticles on zebrafish exposed to a spiked sediment

hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorDEDEH, Amina
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorCIUTAT, Aurélie
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorTRÉGUER-DELAPIERRE, Mona
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBOURDINEAUD, Jean-Paul
dc.date.issued2013-11-21
dc.identifier.issn1743-5390
dc.description.abstractEnIncreasing use of metallic nanomaterials is likely to result in release of these particles into aquatic environments; nevertheless it is unclear whether these materials present a hazard to aquatic organisms. The impact of contaminated sediment containing 14-nm gold nanoparticles (AuNPs) was investigated in the zebrafish Danio rerio exposed for 20 days to two concentrations, 16 and 55 µg/g dry weight. AuNPs were released from the sediment to the water column, and during this period the mean concentrations of AuNP in the filtered water fraction were 0.25 ± 0.05 and 0.8 ± 0.1 µg/L, respectively. A similar experiment with ionic gold contamination was simultaneously performed to obtain a positive control. AuNP exposure triggered various effects in fish tissues including modifications of genome composition, shown using a random amplified polymorphic DNA-PCR genotoxicity test. Expression of genes involved in oxidative stress, mitochondrial metabolism, detoxification and DNA repair were also modulated in response to AuNP contamination. Gold altered neurotransmission, since brain acetylcholine esterase activity increased for both tested doses of AuNP but not for ionic gold. Gold accumulation in fish tissues demonstrated the lower bioavailability of AuNP compared to ionic Au, and underlined the higher toxic potential of the nanoparticle form.
dc.language.isoen
dc.publisherTaylor & Francis
dc.subject.enBioaccumulation
dc.subject.engene expression
dc.subject.engenotoxicity
dc.subject.engold nanoparticles
dc.subject.enneurotransmission
dc.subject.enzebrafish
dc.subject.meshAnimals
dc.subject.meshBrain Chemistry
dc.subject.meshSynaptic Transmission
dc.subject.meshTissue Distribution
dc.subject.meshWater Pollutants, Chemical
dc.subject.meshZebrafish
dc.subject.meshDNA Damage
dc.subject.meshGene Expression
dc.subject.meshGeologic Sediments
dc.subject.meshGold
dc.subject.meshMetal Nanoparticles
dc.subject.meshMuscles
dc.title.enImpact of gold nanoparticles on zebrafish exposed to a spiked sediment
dc.typeArticle de revue
dc.identifier.doi10.3109/17435390.2014.889238
dc.subject.halChimie/Matériaux
bordeaux.journalNanotoxicology
bordeaux.page71-80
bordeaux.volume9
bordeaux.issue1
bordeaux.peerReviewedoui
hal.identifierhal-03739966
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03739966v1
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