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Fine tuning of the relaxometry of γ-Fe2O3@SiO2 nanoparticles by tweaking the silica coating thickness.

hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
hal.structure.identifierDepartments of Chemistry and Physics
dc.contributor.authorPINHO, Sonia L. C.
hal.structure.identifierDepartments of Chemistry and Physics
hal.structure.identifierDepartment of Life Sciences
dc.contributor.authorPEREIRA, Giovannia A
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorVOISIN, Pierre
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorKASSEM, Jinane
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBOUCHAUD, Véronique
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorÉTIENNE, Laetitia
hal.structure.identifierLaboratory of Biocatalysis and Organic Chemistry
dc.contributor.authorPETERS, Joop A.
hal.structure.identifierDepartments of Chemistry and Physics
dc.contributor.authorCARLOS, Luis
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMORNET, Stéphane
hal.structure.identifierDepartment of Life Sciences
dc.contributor.authorGERALDES, Carlos F. G. C.
hal.structure.identifierDepartments of Chemistry and Physics
dc.contributor.authorROCHA, João
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDELVILLE, Marie-Hélène
dc.date.issued2010
dc.identifier.issn1936-0851
dc.description.abstractEnWe report the fine-tuning of the relaxometry of gamma-Fe2O3@SiO2 core-shell nanoparticles by adjusting the thickness of the coated silica layer. It is clear that the coating thickness of Fe2O3@SiO2 nanoparticles has a significant impact on the r(1) (at low B0 fields), r(2), and r(2)* relaxivities of their aqueous suspensions. These studies clearly indicate that the silica layer is heterogeneous and has regions that are porous to water and others-that are not. It is also shown, that the viability and the mitochondrial dehydrogenase expression of the microglial cells do not appear to be sensitive to the vesicular load with these core-shell nanoparticles. The adequate silica-shell thickness can therefore be tuned to allow for both a sufficiently high response as contrast agent, and-adequate grafting of targeted biomolecules.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.title.enFine tuning of the relaxometry of γ-Fe2O3@SiO2 nanoparticles by tweaking the silica coating thickness.
dc.typeArticle de revue
dc.identifier.doi10.1021/nn101129r
dc.subject.halChimie/Matériaux
bordeaux.journalACS Nano
bordeaux.page5339-5349
bordeaux.volume4
bordeaux.issue9
bordeaux.peerReviewedoui
hal.identifierhal-00530395
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00530395v1
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