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Impact of dietary gold nanoparticles in zebrafish at very low contamination pressure: the role of size, concentration and exposure time.

hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGEFFROY, Benjamin
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorLADHAR, Chiraz
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorCAMBIER, Sébastien
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorTRÉGUER-DELAPIERRE, Mona
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorBRÈTHES, Daniel
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBOURDINEAUD, Jean-Paul
dc.date.issued2012
dc.identifier.issn1743-5390
dc.description.abstractEnThe impact of a daily ration of food containing gold nanoparticles (AuNPs) of two sizes (12 and 50 nm) was investigated in the zebrafish Danio rerio at very low doses (from 36-106 ng gold/fish/day). AuNP exposure resulted in various dysfunctions at the sub cellular scale, and AuNP concentration in food, AuNP size and exposure duration modulated the observed adverse effects. Indeed, we showed alteration of genome composition using a RAPD-PCR genotoxicity test as the number of hybridization sites of the RAPD probes was significantly modified after AuNP exposure. Moreover, the expression of genes involved in DNA repair, detoxification processes, apoptosis, mitochondrial metabolism and oxidative stress was also modulated in response to AuNP contamination. Mitochondrial dysfunctions appeared in brain and muscle for both tested doses (40 and 100 ng gold/fish/day), but gold accumulation in fish tissues could only be observed in the case of the highest exposure dose.
dc.language.isoen
dc.publisherTaylor & Francis
dc.title.enImpact of dietary gold nanoparticles in zebrafish at very low contamination pressure: the role of size, concentration and exposure time.
dc.typeArticle de revue
dc.identifier.doi10.3109/17435390.2011.562328
dc.subject.halSciences du Vivant [q-bio]/Biologie cellulaire
bordeaux.journalNanotoxicology
bordeaux.page144-160
bordeaux.volume6
bordeaux.issue2
bordeaux.peerReviewedoui
hal.identifierhal-00586789
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00586789v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nanotoxicology&rft.date=2012&rft.volume=6&rft.issue=2&rft.spage=144-160&rft.epage=144-160&rft.eissn=1743-5390&rft.issn=1743-5390&rft.au=GEFFROY,%20Benjamin&LADHAR,%20Chiraz&CAMBIER,%20S%C3%A9bastien&TR%C3%89GUER-DELAPIERRE,%20Mona&BR%C3%88THES,%20Daniel&rft.genre=article


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