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Control of the PEO chain conformation on nanoparticles by adsorption of PEO-block-poly(l-lysine) copolymers and its significance on colloidal stability and protein repellency

hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorLOUGUET, Stéphanie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorGUIDOLIN, Nicolas
hal.structure.identifierCentre de Recherche Paul Pascal [CRPP]
dc.contributor.authorSIGAUD, Gilles
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDUGUET, Etienne
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sébastien
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSCHATZ, Christophe
dc.date.created2011-11-01
dc.date.issued2011
dc.identifier.issn0743-7463
dc.description.abstractEnThe physical adsorption of PEO(n)-b-PLL(m) copolymers onto silica nanoparticles and the related properties of poly(ethylene oxide) (PEO)-coated particles were studied as a function of the block copolymer composition. Copolymers adopt an anchor-buoy conformation at the particle surface owing to a preferential affinity of poly(l-lysine) (PLL) blocks with the silica surface over PEO blocks when a large excess of copolymer is used. The interdistance between PEO chains at particle surface is highly dependent on the size of PLL segments; a dense brush of PEO is obtained for short PLL blocks (DP = 10), whereas PEO chains adopt a so-called interacting "mushroom" conformation for large PLL blocks (DP = 270). The size of the PEO blocks does not really influence the copolymer surface density, but it has a strong effect on the PEO layer thickness as expected. Salt and protein stability studies led to similar conclusions about the effectiveness of a PEO layer with a dense brush conformation to prevent colloidal aggregation and protein adsorption. Besides, a minimal PEO length is required to get full stabilization properties; as a matter of fact, both PEO(45)-b-PLL(10) and PEO(113)-b-PLL(10) give rise to a PEO brush conformation but only the latter copolymer efficiently stabilizes the particles in the presence of salt or proteins.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.title.enControl of the PEO chain conformation on nanoparticles by adsorption of PEO-block-poly(l-lysine) copolymers and its significance on colloidal stability and protein repellency
dc.typeArticle de revue
dc.identifier.doi10.1021/la202990y
dc.subject.halChimie/Matériaux
dc.subject.halChimie/Polymères
bordeaux.journalLangmuir
bordeaux.page12891-12901
bordeaux.volume27
bordeaux.issue21
bordeaux.peerReviewedoui
hal.identifierhal-00641723
hal.version1
hal.popularnon
hal.audienceInternationale
dc.subject.itPolymer
dc.subject.itCopolymer
dc.subject.itNanoparticle
dc.subject.itSilica
dc.subject.itColloids
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00641723v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Langmuir&rft.date=2011&rft.volume=27&rft.issue=21&rft.spage=12891-12901&rft.epage=12891-12901&rft.eissn=0743-7463&rft.issn=0743-7463&rft.au=LOUGUET,%20St%C3%A9phanie&GUIDOLIN,%20Nicolas&SIGAUD,%20Gilles&DUGUET,%20Etienne&LECOMMANDOUX,%20S%C3%A9bastien&rft.genre=article


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