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Pulsed field ablation prevents chronic atrial fibrotic changes and restrictive mechanics after catheter ablation for atrial fibrillation

dc.rights.licenseopenen_US
dc.contributor.authorNAKATANI, Yosuke
dc.contributor.authorSRIDI-CHENITI, Soumaya
dc.contributor.authorCHENITI, Ghassen
dc.contributor.authorRAMIREZ, Francisco Daniel
dc.contributor.authorGOUJEAU, Cyril
dc.contributor.authorANDRE, Clementine
dc.contributor.authorNAKASHIMA, Takashi
dc.contributor.authorEGGERT, Charles
dc.contributor.authorSCHNEIDER, Christopher
dc.contributor.authorVISWANATHAN, Raju
dc.contributor.authorKRISAI, Philipp
dc.contributor.authorTAKAGI, Takamitsu
dc.contributor.authorKAMAKURA, Tsukasa
dc.contributor.authorVLACHOS, Konstantinos
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDERVAL, Nicolas
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDUCHATEAU, Josselin
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorPAMBRUN, Thomas
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorCHAUVEL, Remi
dc.contributor.authorREDDY, Vivek Y.
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorMONTAUDON, Michel
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorLAURENT, Francois
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorSACHER, Frederic
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorHOCINI, Meleze
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorHAISSAGUERRE, Michel
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorJAIS, Pierre
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorCOCHET, Hubert
dc.date.accessioned2022-10-12T07:39:04Z
dc.date.available2022-10-12T07:39:04Z
dc.date.issued2021-11-01
dc.identifier.issn1099-5129en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/148509
dc.description.abstractEnPulsed field ablation (PFA), a non-thermal ablative modality, may show different effects on the myocardial tissue compared to thermal ablation. Thus, this study aimed to compare the left atrial (LA) structural and mechanical characteristics after PFA vs. thermal ablation.Cardiac magnetic resonance was performed pre-ablation, acutely (<3 h), and 3 months post-ablation in 41 patients with paroxysmal atrial fibrillation (AF) undergoing pulmonary vein (PV) isolation with PFA (n = 18) or thermal ablation (n = 23, 16 radiofrequency ablations, 7 cryoablations). Late gadolinium enhancement (LGE), T2-weighted, and cine images were analysed. In the acute stage, LGE volume was 60% larger after PFA vs. thermal ablation (P < 0.001), and oedema on T2 imaging was 20% smaller (P = 0.002). Tissue changes were more homogeneous after PFA than after thermal ablation, with no sign of microvascular damage or intramural haemorrhage. In the chronic stage, the majority of acute LGE had disappeared after PFA, whereas most LGE persisted after thermal ablation. The maximum strain on PV antra, the LA expansion index, and LA active emptying fraction declined acutely after both PFA and thermal ablation but recovered at the chronic stage only with PFA.Pulsed field ablation induces large acute LGE without microvascular damage or intramural haemorrhage. Most LGE lesions disappear in the chronic stage, suggesting a specific reparative process involving less chronic fibrosis. This process may contribute to a preserved tissue compliance and LA reservoir and booster pump functions.
dc.description.sponsorshipPlateforme multi-modale d'exploration en cardiologieen_US
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaqueen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enAtrial fibrillation
dc.subject.enCatheter ablation
dc.subject.enPulsed field ablation
dc.subject.enCardiac magnetic resonance
dc.subject.enAtrial fibrosis
dc.title.enPulsed field ablation prevents chronic atrial fibrotic changes and restrictive mechanics after catheter ablation for atrial fibrillation
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/europace/euab155en_US
dc.subject.halSciences de l'ingénieur [physics]en_US
dc.identifier.pubmed34240134en_US
dc.description.sponsorshipEuropeElectrostructural Tomography - Towards Multiparametric Imaging of Cardiac Electrical Disordersen_US
bordeaux.journalEP-Europaceen_US
bordeaux.page1767-1776en_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesCentre de Recherche Cardio-Thoracique de Bordeaux (CRCTB) - U 1045en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDEuropean Research Councilen_US
hal.identifierhal-03811670
hal.version1
hal.date.transferred2022-10-12T07:39:10Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=EP-Europace&rft.date=2021-11-01&rft.volume=23&rft.issue=11&rft.spage=1767-1776&rft.epage=1767-1776&rft.eissn=1099-5129&rft.issn=1099-5129&rft.au=NAKATANI,%20Yosuke&SRIDI-CHENITI,%20Soumaya&CHENITI,%20Ghassen&RAMIREZ,%20Francisco%20Daniel&GOUJEAU,%20Cyril&rft.genre=article


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