Gold nanorods with phase-changing polymer corona for remotely near-infrared-triggered drug release.
| hal.structure.identifier | Centre d'Etude et de Recherche sur les Macromolécules [CERM] | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | LIU, Ji | |
| hal.structure.identifier | Centre d'Etude et de Recherche sur les Macromolécules [CERM] | |
| dc.contributor.author | DETREMBLEUR, Christophe | |
| hal.structure.identifier | Centre d'Etude et de Recherche sur les Macromolécules [CERM] | |
| dc.contributor.author | GRIGNARD, Bruno | |
| hal.structure.identifier | Laboratory of Mammalian Cell Culture [GIGA-R] | |
| dc.contributor.author | DE PAUW-GILLET, Marie-Claire | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | MORNET, Stéphane | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | TRÉGUER-DELAPIERRE, Mona | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | PETIT, Yannick | |
| hal.structure.identifier | Centre d'Etude et de Recherche sur les Macromolécules [CERM] | |
| dc.contributor.author | JÉRÔME, Christine | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | DUGUET, Etienne | |
| dc.date.issued | 2014 | |
| dc.identifier.issn | 1861-4728 | |
| dc.description.abstractEn | Herein, we report a new drug-delivery system (DDS) that is comprised of a near-infrared (NIR)-light-sensitive gold-nanorod (GNR) core and a phase-changing poly(ε-caprolactone)-b-poly(ethylene glycol) polymer corona (GNR@PCL-b-PEG). The underlying mechanism of the drug-loading and triggered-release behaviors involves the entrapment of drug payloads among the PCL crystallites and a heat-induced phase change, respectively. A low premature release of the pre-loaded doxorubicin was observed in PBS buffer (pH 7.4) at 37 °C (<10% of the entire payload after 48 h). However, release could be activated within 30 min by conventional heating at 50 °C, above the Tm of the crystalline PCL domain (43.5 °C), with about 60% release over the subsequent 42 h at 37 °C. The NIR-induced heating of an aqueous suspension of GNR@PCL-b-PEG under NIR irradiation (802 nm) was investigated in terms of the irradiation period, power, and concentration-dependent heating behavior, as well as the NIR-induced shape-transformation of the GNR cores. Remotely NIR-triggered release was also explored upon NIR irradiation for 30 min and about 70% release was achieved in the following 42 h at 37 °C, with a mild warming (<4 °C) of the surroundings. The cytotoxicity of GNR@PCL-b-PEG against the mouse fibroblastic-like L929 cell-line was assessed by MTS assay and good compatibility was confirmed with a cell viability of over 90% after incubation for 72 h. The cellular uptake of GNR@PCL-b-PEG by melanoma MEL-5 cells was also confirmed, with an averaged uptake of 1250(±110) particles cell(-1) after incubation for 12 h (50 μg mL(-1)). This GNR@PCL-b-PEG DDS is aimed at addressing the different requirements for therapeutic treatments and is envisaged to provide new insights into DDS targeting for remotely triggered release by NIR activation. | |
| dc.language.iso | en | |
| dc.publisher | Wiley-VCH Verlag | |
| dc.subject.en | Drug delivery | |
| dc.subject.en | Gold | |
| dc.subject.en | Nanorods | |
| dc.subject.en | Phase transitions | |
| dc.subject.en | Polymers | |
| dc.title.en | Gold nanorods with phase-changing polymer corona for remotely near-infrared-triggered drug release. | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1002/asia.201301010 | |
| dc.subject.hal | Chimie/Matériaux | |
| bordeaux.journal | Chemistry - An Asian Journal | |
| bordeaux.page | 275-288 | |
| bordeaux.volume | 9 | |
| bordeaux.issue | 1 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00949267 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00949267v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Chemistry%20-%20An%20Asian%20Journal&rft.date=2014&rft.volume=9&rft.issue=1&rft.spage=275-288&rft.epage=275-288&rft.eissn=1861-4728&rft.issn=1861-4728&rft.au=LIU,%20Ji&DETREMBLEUR,%20Christophe&GRIGNARD,%20Bruno&DE%20PAUW-GILLET,%20Marie-Claire&MORNET,%20St%C3%A9phane&rft.genre=article |
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