Neuroprotective role of lactate in rat neonatal hypoxia-ischemia
| dc.rights.license | open | en_US |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | ROUMES, Helene | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | DUMONT, Ursule | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | SANCHEZ, Stephane | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | MAZUEL, Leslie | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | BLANC, Jordy | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | RAFFARD, Gerard | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | CHATEIL, Jean-Francois | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | PELLERIN, Luc | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | BOUZIER-SORE, Anne-Karine | |
| dc.date.accessioned | 2022-10-11T15:06:57Z | |
| dc.date.available | 2022-10-11T15:06:57Z | |
| dc.date.issued | 2020-03-24 | |
| dc.identifier.issn | 0271-678X | en_US |
| dc.identifier.uri | oai:crossref.org:10.1177/0271678x20908355 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/148383 | |
| dc.description.abstractEn | Hypoxic-ischemic (HI) encephalopathy remains a major cause of perinatal mortality and chronic disability in newborns worldwide (1–6 for 1000 births). The only current clinical treatment is hypothermia, which is efficient for less than 60% of babies. Mainly considered as a waste product in the past, lactate, in addition to glucose, is increasingly admitted as a supplementary fuel for neurons and, more recently, as a signaling molecule in the brain. Our aim was to investigate the neuroprotective effect of lactate in a neonatal (seven day old) rat model of hypoxia-ischemia. Pups received intra-peritoneal injection(s) of lactate (40 μmol). Size and apparent diffusion coefficients of brain lesions were assessed by magnetic resonance diffusion-weighted imaging. Oxiblot analyses and long-term behavioral studies were also conducted. A single lactate injection induced a 30% reduction in brain lesion volume, indicating a rapid and efficient neuroprotective effect. When oxamate, a lactate dehydrogenase inhibitor, was co-injected with lactate, the neuroprotection was completely abolished, highlighting the role of lactate metabolism in this protection. After three lactate injections (one per day), pups presented the smallest brain lesion volume and a complete recovery of neurological reflexes, sensorimotor capacities and long-term memory, demonstrating that lactate administration is a promising therapy for neonatal HI insult. | |
| dc.description.sponsorship | Translational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057 | en_US |
| dc.description.sponsorship | Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003 | en_US |
| dc.description.sponsorship | Exploration in vivo du couplage métabolique entre neurones et astrocytes lors de l'activation cérébrale: étude par spectroscopie de RMN - ANR-15-CE37-0012 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
| dc.source | crossref | |
| dc.subject.en | Neonatal hypoxia-ischemia | |
| dc.subject.en | Lactate | |
| dc.subject.en | Neuroprotection | |
| dc.subject.en | Astrocyte to neuron lactate shuttle | |
| dc.subject.en | MRI | |
| dc.title.en | Neuroprotective role of lactate in rat neonatal hypoxia-ischemia | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1177/0271678x20908355 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio] | en_US |
| dc.identifier.pubmed | 32208801 | en_US |
| bordeaux.journal | Journal of Cerebral Blood Flow and Metabolism | en_US |
| bordeaux.page | 342-358 | en_US |
| bordeaux.volume | 41 | en_US |
| bordeaux.hal.laboratories | Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | dissemin | |
| hal.export | false | |
| workflow.import.source | dissemin | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Cerebral%20Blood%20Flow%20and%20Metabolism&rft.date=2020-03-24&rft.volume=41&rft.issue=2&rft.spage=342-358&rft.epage=342-358&rft.eissn=0271-678X&rft.issn=0271-678X&rft.au=ROUMES,%20Helene&DUMONT,%20Ursule&SANCHEZ,%20Stephane&MAZUEL,%20Leslie&BLANC,%20Jordy&rft.genre=article |
