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International electronic health record-derived post-acute sequelae profiles of COVID-19 patients
dc.rights.license | open | en_US |
dc.contributor.author | ZHANG, Harrison G. | |
dc.contributor.author | DAGLIATI, Arianna | |
dc.contributor.author | SHAKERI HOSSEIN ABAD, Zahra | |
dc.contributor.author | XIONG, Xin | |
dc.contributor.author | BONZEL, Clara-Lea | |
dc.contributor.author | XIA, Zongqi | |
dc.contributor.author | TAN, Bryce W. Q. | |
dc.contributor.author | AVILLACH, Paul | |
dc.contributor.author | BRAT, Gabriel A. | |
dc.contributor.author | HONG, Chuan | |
dc.contributor.author | MORRIS, Michele | |
dc.contributor.author | VISWESWARAN, Shyam | |
dc.contributor.author | PATEL, Lav P. | |
dc.contributor.author | GUTIERREZ-SACRISTAN, Alba | |
dc.contributor.author | HANAUER, David A. | |
dc.contributor.author | HOLMES, John H. | |
dc.contributor.author | SAMAYAMUTHU, Malarkodi Jebathilagam | |
dc.contributor.author | BOURGEOIS, Florence T. | |
dc.contributor.author | L'YI, Sehi | |
dc.contributor.author | MAIDLOW, Sarah E. | |
dc.contributor.author | MOAL, Bertrand | |
dc.contributor.author | MURPHY, Shawn N. | |
dc.contributor.author | STRASSER, Zachary H. | |
dc.contributor.author | NEURAZ, Antoine | |
dc.contributor.author | NGIAM, Kee Yuan | |
dc.contributor.author | LOH, Ne Hooi Will | |
dc.contributor.author | OMENN, Gilbert S. | |
dc.contributor.author | PRUNOTTO, Andrea | |
dc.contributor.author | DALVIN, Lauren A. | |
dc.contributor.author | KLANN, Jeffrey G. | |
dc.contributor.author | SCHUBERT, Petra | |
dc.contributor.author | VIDORRETA, Fernando J. Sanz | |
dc.contributor.author | BENOIT, Vincent | |
dc.contributor.author | VERDY, Guillaume | |
dc.contributor.author | KAVULURU, Ramakanth | |
dc.contributor.author | ESTIRI, Hossein | |
dc.contributor.author | LUO, Yuan | |
dc.contributor.author | MALOVINI, Alberto | |
dc.contributor.author | TIBOLLO, Valentina | |
dc.contributor.author | BELLAZZI, Riccardo | |
dc.contributor.author | CHO, Kelly | |
dc.contributor.author | HO, Yuk-Lam | |
dc.contributor.author | TAN, Amelia L. M. | |
dc.contributor.author | TAN, Byorn W. L. | |
dc.contributor.author | GEHLENBORG, Nils | |
dc.contributor.author | LOZANO-ZAHONERO, Sara | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | JOUHET, Vianney | |
dc.contributor.author | CHIOVATO, Luca | |
dc.contributor.author | ARONOW, Bruce J. | |
dc.contributor.author | TOH, Emma M. S. | |
dc.contributor.author | WONG, Wei Gen Scott | |
dc.contributor.author | PIZZIMENTI, Sara | |
dc.contributor.author | WAGHOLIKAR, Kavishwar B | |
dc.contributor.author | BUCALO, Mauro | |
dc.contributor.author | CAI, Tianxi | |
dc.contributor.author | SOUTH, Andrew M. | |
dc.contributor.author | KOHANE, Isaac S. | |
dc.contributor.author | WEBER, Griffin M. | |
dc.date.accessioned | 2022-07-13T08:26:50Z | |
dc.date.available | 2022-07-13T08:26:50Z | |
dc.date.issued | 2022-06-29 | |
dc.identifier.issn | 2398-6352 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140463 | |
dc.description.abstractEn | The risk profiles of post-acute sequelae of COVID-19 (PASC) have not been well characterized in multi-national settings with appropriate controls. We leveraged electronic health record (EHR) data from 277 international hospitals representing 414,602 patients with COVID-19, 2.3 million control patients without COVID-19 in the inpatient and outpatient settings, and over 221 million diagnosis codes to systematically identify new-onset conditions enriched among patients with COVID-19 during the post-acute period. Compared to inpatient controls, inpatient COVID-19 cases were at significant risk for angina pectoris (RR 1.30, 95% CI 1.09-1.55), heart failure (RR 1.22, 95% CI 1.10-1.35), cognitive dysfunctions (RR 1.18, 95% CI 1.07-1.31), and fatigue (RR 1.18, 95% CI 1.07-1.30). Relative to outpatient controls, outpatient COVID-19 cases were at risk for pulmonary embolism (RR 2.10, 95% CI 1.58-2.76), venous embolism (RR 1.34, 95% CI 1.17-1.54), atrial fibrillation (RR 1.30, 95% CI 1.13-1.50), type 2 diabetes (RR 1.26, 95% CI 1.16-1.36) and vitamin D deficiency (RR 1.19, 95% CI 1.09-1.30). Outpatient COVID-19 cases were also at risk for loss of smell and taste (RR 2.42, 95% CI 1.90-3.06), inflammatory neuropathy (RR 1.66, 95% CI 1.21-2.27), and cognitive dysfunction (RR 1.18, 95% CI 1.04-1.33). The incidence of post-acute cardiovascular and pulmonary conditions decreased across time among inpatient cases while the incidence of cardiovascular, digestive, and metabolic conditions increased among outpatient cases. Our study, based on a federated international network, systematically identified robust conditions associated with PASC compared to control groups, underscoring the multifaceted cardiovascular and neurological phenotype profiles of PASC. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.title.en | International electronic health record-derived post-acute sequelae profiles of COVID-19 patients | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1038/s41746-022-00623-8 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 35768548 | en_US |
bordeaux.journal | npj Digital Medicine | en_US |
bordeaux.volume | 5 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 81 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | AHEAD_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-03722096 | |
hal.version | 1 | |
hal.date.transferred | 2022-07-13T08:27:20Z | |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
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