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The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
dc.rights.license | open | en_US |
dc.contributor.author | MANRY, Jeremy | |
dc.contributor.author | BASTARD, Paul | |
dc.contributor.author | GERVAIS, Adrian | |
dc.contributor.author | LE VOYER, Tom | |
dc.contributor.author | ROSAIN, Jeremie | |
dc.contributor.author | PHILIPPOT, Quentin | |
dc.contributor.author | MICHAILIDIS, Eleftherios | |
dc.contributor.author | HOFFMANN, Hans-Heinrich | |
dc.contributor.author | ETO, Shohei | |
dc.contributor.author | GARCIA-PRAT, Marina | |
dc.contributor.author | BIZIEN, Lucy | |
dc.contributor.author | PARRA-MARTINEZ, Alba | |
dc.contributor.author | YANG, Rui | |
dc.contributor.author | HALJASMAGI, Liis | |
dc.contributor.author | MIGAUD, Melanie | |
dc.contributor.author | SAREKANNU, Karita | |
dc.contributor.author | MASLOVSKAJA, Julia | |
dc.contributor.author | DE PROST, Nicolas | |
dc.contributor.author | TANDJAOUI-LAMBIOTTE, Yacine | |
dc.contributor.author | LUYT, Charles-Edouard | |
dc.contributor.author | AMADOR-BORRERO, Blanca | |
dc.contributor.author | GAUDET, Alexandre | |
dc.contributor.author | POISSY, JULIEN | |
dc.contributor.author | MOREL, Pascal | |
dc.contributor.author | RICHARD, Pascale | |
dc.contributor.author | COGNASSE, Fabrice | |
dc.contributor.author | TROYA, Jesus | |
dc.contributor.author | TROUILLET-ASSANT, Sophie | |
dc.contributor.author | BELOT, Alexandre | |
dc.contributor.author | SAKER, Kahina | |
dc.contributor.author | GARCON, Pierre | |
dc.contributor.author | RIVIERE, Jacques G. | |
dc.contributor.author | LAGIER, Jean-Christophe | |
dc.contributor.author | GENTILE, Stephanie | |
dc.contributor.author | ROSEN, Lindsey B. | |
dc.contributor.author | SHAW, Elana | |
dc.contributor.author | MORIO, Tomohiro | |
dc.contributor.author | TANAKA, Junko | |
dc.contributor.author | DALMAU, David | |
dc.contributor.author | THARAUX, Pierre-Louis | |
dc.contributor.author | SENE, Damien | |
dc.contributor.author | STEPANIAN, Alain | |
dc.contributor.author | MEGARBANE, Bruno | |
dc.contributor.author | TRIANTAFYLLIA, Vasiliki | |
dc.contributor.author | FEKKAR, Arnaud | |
dc.contributor.author | HEATH, James R. | |
dc.contributor.author | FRANCO, Jose Luis | |
dc.contributor.author | ANAYA, Juan-Manuel | |
dc.contributor.author | SOLE-VIOLAN, Jordi | |
dc.contributor.author | IMBERTI, Luisa | |
dc.contributor.author | BIONDI, Andrea | |
dc.contributor.author | BONFANTI, Paolo | |
dc.contributor.author | CASTAGNOLI, Riccardo | |
dc.contributor.author | DELMONTE, Ottavia M. | |
dc.contributor.author | ZHANG, Yu | |
dc.contributor.author | SNOW, Andrew L. | |
dc.contributor.author | HOLLAND, Steven M. | |
dc.contributor.author | BIGGS, Catherine M. | |
dc.contributor.author | MONCADA-VELEZ, Marcela | |
dc.contributor.author | ARIAS, Andres Augusto | |
dc.contributor.author | LORENZO, Lazaro | |
dc.contributor.author | BOUCHERIT, Soraya | |
dc.contributor.author | ANGLICHEAU, Dany | |
dc.contributor.author | PLANAS, Anna M. | |
dc.contributor.author | HAERYNCK, Filomeen | |
dc.contributor.author | DUVLIS, Sotirija | |
dc.contributor.author | OZCELIK, Tayfun | |
dc.contributor.author | KELES, Sevgi | |
dc.contributor.author | BOUSFIHA, Ahmed A. | |
dc.contributor.author | EL BAKKOURI, Jalila | |
dc.contributor.author | RAMIREZ-SANTANA, Carolina | |
dc.contributor.author | PAUL, Stephane | |
dc.contributor.author | PAN-HAMMARSTROM, Qiang | |
dc.contributor.author | HAMMARSTROM, Lennart | |
dc.contributor.author | DUPONT, Annabelle | |
dc.contributor.author | KUROLAP, Alina | |
dc.contributor.author | METZ, Christine N. | |
dc.contributor.author | AIUTI, Alessandro | |
dc.contributor.author | CASARI, Giorgio | |
dc.contributor.author | LAMPASONA, Vito | |
dc.contributor.author | CICERI, Fabio | |
dc.contributor.author | BARREIROS, Lucila A. | |
dc.contributor.author | DOMINGUEZ-GARRIDO, Elena | |
dc.contributor.author | VIDIGAL, Mateus | |
dc.contributor.author | ZATZ, Mayana | |
dc.contributor.author | VAN DE BEEK, Diederik | |
dc.contributor.author | SAHANIC, Sabina | |
dc.contributor.author | TANCEVSKI, Ivan | |
dc.contributor.author | STEPANOVSKYY, Yurii | |
dc.contributor.author | BOYARCHUK, Oksana | |
dc.contributor.author | NUKUI, Yoko | |
dc.contributor.author | TSUMURA, Miyuki | |
dc.contributor.author | VIDAUR, Loreto | |
dc.contributor.author | TANGYE, Stuart G. | |
dc.contributor.author | BURREL, Sonia | |
dc.contributor.author | DUFFY, Darragh | |
dc.contributor.author | QUINTANA-MURCI, Lluis | |
dc.contributor.author | KLOCPERK, Adam | |
dc.contributor.author | KANN, Nelli Y. | |
dc.contributor.author | SHCHERBINA, Anna | |
dc.contributor.author | LAU, Yu-Lung | |
dc.contributor.author | LEUNG, Daniel | |
dc.contributor.author | COULONGEAT, Matthieu | |
dc.contributor.author | MARLET, Julien | |
dc.contributor.author | KONING, Rutger | |
dc.contributor.author | REYES, Luis Felipe | |
dc.contributor.author | CHAUVINEAU-GRENIER, Angelique | |
dc.contributor.author | VENET, Fabienne | |
dc.contributor.author | MONNERET, Guillaume | |
dc.contributor.author | NUSSENZWEIG, Michel C. | |
dc.contributor.author | ARRESTIER, Romain | |
dc.contributor.author | BOUDHABHAY, Idris | |
dc.contributor.author | BARIS-FELDMAN, Hagit | |
dc.contributor.author | HAGIN, David | |
dc.contributor.author | WAUTERS, Joost | |
dc.contributor.author | MEYTS, Isabelle | |
dc.contributor.author | DYER, Adam H. | |
dc.contributor.author | KENNELLY, Sean P. | |
dc.contributor.author | BOURKE, Nollaig M. | |
dc.contributor.author | HALWANI, Rabih | |
dc.contributor.author | SHARIF-ASKARI, Fatemeh Saheb | |
dc.contributor.author | DORGHAM, Karim | |
dc.contributor.author | SALLETTE, Jerome | |
dc.contributor.author | SEDKAOUI, Souad Mehlal | |
dc.contributor.author | ALKHATER, Suzan | |
dc.contributor.author | RIGO-BONNIN, Raul | |
dc.contributor.author | MORANDEIRA, Francisco | |
dc.contributor.author | ROUSSEL, Lucie | |
dc.contributor.author | VINH, Donald C. | |
dc.contributor.author | ERIKSTRUP, Christian | |
dc.contributor.author | CONDINO-NETO, Antonio | |
dc.contributor.author | PRANDO, Carolina | |
dc.contributor.author | BONDARENKO, Anastasiia | |
dc.contributor.author | SPAAN, Andras N. | |
dc.contributor.author | GILARDIN, Laurent | |
dc.contributor.author | FELLAY, Jacques | |
dc.contributor.author | LYONNET, Stanislas | |
dc.contributor.author | BILGUVAR, Kaya | |
dc.contributor.author | LIFTON, Richard P. | |
dc.contributor.author | MANE, Shrikant | |
dc.contributor.author | ANDERSON, Mark S. | |
dc.contributor.author | BOISSON, Bertrand | |
dc.contributor.author | BEZIAT, Vivien | |
dc.contributor.author | ZHANG, Shen-Ying | |
dc.contributor.author | ANDREAKOS, Evangelos | |
dc.contributor.author | HERMINE, Olivier | |
dc.contributor.author | PUJOL, Aurora | |
dc.contributor.author | PETERSON, Part | |
dc.contributor.author | MOGENSEN, Trine H. | |
dc.contributor.author | ROWEN, Lee | |
dc.contributor.author | MOND, James | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DEBETTE, Stephanie | |
dc.contributor.author | DE LAMBALLERIE, Xavier | |
dc.contributor.author | BURDET, Charles | |
dc.contributor.author | BOUADMA, Lila | |
dc.contributor.author | ZINS, Marie | |
dc.contributor.author | SOLER-PALACIN, Pere | |
dc.contributor.author | COLOBRAN, Roger | |
dc.contributor.author | GOROCHOV, Guy | |
dc.contributor.author | SOLANICH, Xavier | |
dc.contributor.author | SUSEN, Sophie | |
dc.contributor.author | MARTINEZ-PICADO, Javier | |
dc.contributor.author | RAOULT, Didier | |
dc.contributor.author | VASSE, Marc | |
dc.contributor.author | GREGERSEN, Peter K. | |
dc.contributor.author | PIEMONTI, Lorenzo | |
dc.contributor.author | RODRIGUEZ-GALLEGO, Carlos | |
dc.contributor.author | NOTARANGELO, Luigi D. | |
dc.contributor.author | SU, Helen C. | |
dc.contributor.author | KISAND, Kai | |
dc.contributor.author | OKADA, Satoshi | |
dc.contributor.author | PUEL, Anne | |
dc.contributor.author | JOUANGUY, Emmanuelle | |
dc.contributor.author | RICE, Charles M. | |
dc.contributor.author | TIBERGHIEN, Pierre | |
dc.contributor.author | ZHANG, Qian | |
dc.contributor.author | CASANOVA, Jean-Laurent | |
dc.contributor.author | ABEL, Laurent | |
dc.contributor.author | COBAT, Aurelie | |
dc.date.accessioned | 2022-06-21T14:04:34Z | |
dc.date.available | 2022-06-21T14:04:34Z | |
dc.date.issued | 2022-05-16 | |
dc.identifier.issn | 1091-6490 (Electronic) 0027-8424 (Linking) | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140297 | |
dc.description.abstractEn | SignificanceThere is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 International (CC BY 3.0) | |
dc.rights | Attribution 3.0 International (CC BY 3.0) | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | |
dc.title.en | The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1073/pnas.2200413119 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 35576468 | en_US |
bordeaux.journal | Proceedings of the National Academy of Sciences of the United States of America | en_US |
bordeaux.volume | 119 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 21 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | ELEANOR_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-03701064 | |
hal.version | 1 | |
hal.export | false | |
dc.rights.cc | Pas de Licence CC | en_US |
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