Differential prognostic burden of cardiovascular disease and lower-limb amputation on the risk of all-cause death in people with long-standing type 1 diabetes
| dc.rights.license | open | en_US |
| dc.contributor.author | CAMOIN, Marion | |
| dc.contributor.author | VELHO, Gilberto | |
| dc.contributor.author | SAULNIER, Pierre-Jean | |
| dc.contributor.author | POTIER, Louis | |
| dc.contributor.author | ABOULEKA, Yawa | |
| dc.contributor.author | CARPENTIER, Charlyne | |
| dc.contributor.author | DUBOIS, Severine | |
| dc.contributor.author | LARROUMET, Alice | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | RIGALLEAU, Vincent | |
| dc.contributor.author | GAND, Elise | |
| dc.contributor.author | BOURRON, Olivier | |
| dc.contributor.author | BORDIER, Lyse | |
| dc.contributor.author | SCHEEN, Andre | |
| dc.contributor.author | HADJADJ, Samy | |
| dc.contributor.author | ROUSSEL, Ronan | |
| dc.contributor.author | MARRE, Michel | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | MOHAMMEDI, Kamel | |
| dc.date.accessioned | 2022-06-17T12:58:27Z | |
| dc.date.available | 2022-06-17T12:58:27Z | |
| dc.date.issued | 2022-05-09 | |
| dc.identifier.issn | 1475-2840 (Electronic) 1475-2840 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140271 | |
| dc.description.abstractEn | BACKGROUND: Cardiovascular disease (CVD) and nontraumatic lower-limb amputation (LLA) each results in reduced life expectancy in patients with type 1 diabetes, but the differential burden between these conditions is unknown. We compared the effects of CVD and LLA on the risk of mortality in people with type 1 diabetes. METHODS: We used pooled data from the SURGENE, GENEDIAB, and GENESIS prospective cohorts. Data were divided into: 1/absence of CVD (myocardial infarction and/or stroke) nor LLA, 2/history of CVD alone without LLA, 3/LLA alone without CVD or 4/both conditions at baseline. Participants with baseline history of peripheral artery disease were excluded from groups 1 and 2. The study endpoint was any death occurring during follow-up, regardless of the causes. RESULTS: Among 1169 participants (male 55%, age 40 ± 13 years, diabetes duration 23 ± 11 years), CVD, LLA or both were present at baseline in 49 (4.2%), 62 (5.3%) and 20 (1.7%) subjects, respectively. All-cause death occurred in 304 (26%) participants during 17-year follow-up, corresponding to 18,426 person-years and an incidence rate of 16 (95%CI, 15-18) per 1000 person-years. The risk of death increased in individuals with baseline history of CVD (adjusted HR 2.00 [95% CI 1.34-3.01], p = 0.0008) or LLA (2.26 [1.56-3.28], p < 0.0001), versus no condition, with an additive effect in people with both conditions (5.32 [3.14-9.00], p < 0.0001). No incremental risk of death was observed in people with CVD versus LLA (0.87 [0.54-1.41]). Compared with no condition, CVD and LLA were similarly associated with reduced life expectancy during follow-up: 2.79 (95% CI 1.26-4.32) and 3.38 (1.87-4.88) years, respectively. Combined conditions expose to 7.04 (4.76-9.31) less years of life expectancy (all p < 0.0001). CONCLUSIONS: CVD and LLA conferred a similar burden regarding mortality in type 1 diabetes population. Our findings encourage a careful consideration of people with type 1 diabetes and LLA as usually recommended for those with CVD, in terms of management of risk factors, treatments and prevention. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Lower-limb amputation | |
| dc.subject.en | Cardiovascular disease | |
| dc.subject.en | Mortality | |
| dc.subject.en | Myocardial infarction | |
| dc.subject.en | Stroke | |
| dc.subject.en | Type 1 diabetes mellitus | |
| dc.title.en | Differential prognostic burden of cardiovascular disease and lower-limb amputation on the risk of all-cause death in people with long-standing type 1 diabetes | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1186/s12933-022-01487-8 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35534880 | en_US |
| bordeaux.journal | Cardiovascular Diabetology | en_US |
| bordeaux.page | 71 | en_US |
| bordeaux.volume | 21 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03698441 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-06-17T22:22:21Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cardiovascular%20Diabetology&rft.date=2022-05-09&rft.volume=21&rft.issue=1&rft.spage=71&rft.epage=71&rft.eissn=1475-2840%20(Electronic)%201475-2840%20(Linking)&rft.issn=1475-2840%20(Electronic)%201475-2840%20(Linking)&rft.au=CAMOIN,%20Marion&VELHO,%20Gilberto&SAULNIER,%20Pierre-Jean&POTIER,%20Louis&ABOULEKA,%20Yawa&rft.genre=article |
