B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS
dc.rights.license | open | en_US |
dc.contributor.author | WANG, Sophia S. | |
dc.contributor.author | VAJDIC, Claire M. | |
dc.contributor.author | LINET, Martha S. | |
dc.contributor.author | SLAGER, Susan L. | |
dc.contributor.author | VOUTSINAS, Jenna | |
dc.contributor.author | NIETERS, Alexandra | |
dc.contributor.author | CASABONNE, Delphine | |
dc.contributor.author | CERHAN, James R. | |
dc.contributor.author | COZEN, Wendy | |
dc.contributor.author | ALARCON, Graciela | |
dc.contributor.author | MARTINEZ-MAZA, Otoniel | |
dc.contributor.author | BROWN, Elizabeth E. | |
dc.contributor.author | BRACCI, Paige M. | |
dc.contributor.author | TURNER, Jennifer | |
dc.contributor.author | HJALGRIM, Henrik | |
dc.contributor.author | BHATTI, Parveen | |
dc.contributor.author | ZHANG, Yawei | |
dc.contributor.author | BIRMANN, Brenda M. | |
dc.contributor.author | FLOWERS, Christopher R. | |
dc.contributor.author | PALTIEL, Ora | |
dc.contributor.author | HOLLY, Elizabeth A. | |
dc.contributor.author | KANE, Eleanor | |
dc.contributor.author | WEISENBURGER, Dennis D. | |
dc.contributor.author | MAYNADIE, Marc | |
dc.contributor.author | COCCO, Pierluigi | |
dc.contributor.author | FORETOVA, Lenka | |
dc.contributor.author | BREEN, Elizabeth Crabb | |
dc.contributor.author | LAN, Qing | |
dc.contributor.author | BROOKS-WILSON, Angela | |
dc.contributor.author | DE ROOS, Anneclaire J. | |
dc.contributor.author | SMITH, Martyn T. | |
dc.contributor.author | ROMAN, Eve | |
dc.contributor.author | BOFFETTA, Paolo | |
dc.contributor.author | KRICKER, Anne | |
dc.contributor.author | ZHENG, Tongzhang | |
dc.contributor.author | SKIBOLA, Christine F. | |
dc.contributor.author | CLAVEL, Jacqueline | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | MONNEREAU, Alain | |
dc.contributor.author | CHANOCK, Stephen J. | |
dc.contributor.author | ROTHMAN, Nathaniel | |
dc.contributor.author | BENAVENTE, Yolanda | |
dc.contributor.author | HARTGE, Patricia | |
dc.contributor.author | SMEDBY, Karin E. | |
dc.date.accessioned | 2022-06-17T11:34:17Z | |
dc.date.available | 2022-06-17T11:34:17Z | |
dc.date.issued | 2022-05-04 | |
dc.identifier.issn | 1538-7755 (Electronic) 1055-9965 (Linking) | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140265 | |
dc.description.abstractEn | BACKGROUND: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non-Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes. METHODS: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell-mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n = 1,914), follicular lymphoma (n = 1,733), and marginal zone lymphoma (MZL; n = 407), using unconditional logistic regression. RESULTS: We demonstrated a positive association of DLBCL PRS with DLBCL risk [T2 vs. T1: OR = 1.24; 95% confidence interval (CI), 1.08-1.43; T3 vs. T1: OR = 1.81; 95% CI, 1.59-2.07; P-trend (Ptrend) < 0.0001]. DLBCL risk also increased with increasing PRS tertile among those with an autoimmune condition, being highest for those with a B-cell-mediated autoimmune condition and a T3 PRS [OR = 6.46 vs. no autoimmune condition and a T1 PRS, Ptrend < 0.0001, P-interaction (Pinteraction) = 0.49]. Follicular lymphoma and MZL risk demonstrated no evidence of joint associations or significant Pinteraction. CONCLUSIONS: Our results suggest that PRS constructed from currently known subtype-specific loci may not necessarily capture biological pathways shared with autoimmune conditions. IMPACT: Targeted genetic (PRS) screening among population subsets with autoimmune conditions may offer opportunities for identifying those at highest risk for (and early detection from) DLBCL. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.title.en | B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1158/1055-9965.Epi-21-0875 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 35244686 | en_US |
bordeaux.journal | Cancer Epidemiology, Biomarkers and Prevention | en_US |
bordeaux.page | 1103-1110 | en_US |
bordeaux.volume | 31 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 5 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | EPICENE_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | European Commission | en_US |
bordeaux.identifier.funderID | European Regional Development Fund | en_US |
bordeaux.identifier.funderID | National Cancer Institute | en_US |
hal.identifier | hal-03697957 | |
hal.version | 2 | |
hal.date.transferred | 2022-06-17T22:22:15Z | |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
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