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B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS

dc.rights.licenseopenen_US
dc.contributor.authorWANG, Sophia S.
dc.contributor.authorVAJDIC, Claire M.
dc.contributor.authorLINET, Martha S.
dc.contributor.authorSLAGER, Susan L.
dc.contributor.authorVOUTSINAS, Jenna
dc.contributor.authorNIETERS, Alexandra
dc.contributor.authorCASABONNE, Delphine
dc.contributor.authorCERHAN, James R.
dc.contributor.authorCOZEN, Wendy
dc.contributor.authorALARCON, Graciela
dc.contributor.authorMARTINEZ-MAZA, Otoniel
dc.contributor.authorBROWN, Elizabeth E.
dc.contributor.authorBRACCI, Paige M.
dc.contributor.authorTURNER, Jennifer
dc.contributor.authorHJALGRIM, Henrik
dc.contributor.authorBHATTI, Parveen
dc.contributor.authorZHANG, Yawei
dc.contributor.authorBIRMANN, Brenda M.
dc.contributor.authorFLOWERS, Christopher R.
dc.contributor.authorPALTIEL, Ora
dc.contributor.authorHOLLY, Elizabeth A.
dc.contributor.authorKANE, Eleanor
dc.contributor.authorWEISENBURGER, Dennis D.
dc.contributor.authorMAYNADIE, Marc
dc.contributor.authorCOCCO, Pierluigi
dc.contributor.authorFORETOVA, Lenka
dc.contributor.authorBREEN, Elizabeth Crabb
dc.contributor.authorLAN, Qing
dc.contributor.authorBROOKS-WILSON, Angela
dc.contributor.authorDE ROOS, Anneclaire J.
dc.contributor.authorSMITH, Martyn T.
dc.contributor.authorROMAN, Eve
dc.contributor.authorBOFFETTA, Paolo
dc.contributor.authorKRICKER, Anne
dc.contributor.authorZHENG, Tongzhang
dc.contributor.authorSKIBOLA, Christine F.
dc.contributor.authorCLAVEL, Jacqueline
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMONNEREAU, Alain
dc.contributor.authorCHANOCK, Stephen J.
dc.contributor.authorROTHMAN, Nathaniel
dc.contributor.authorBENAVENTE, Yolanda
dc.contributor.authorHARTGE, Patricia
dc.contributor.authorSMEDBY, Karin E.
dc.date.accessioned2022-06-17T11:34:17Z
dc.date.available2022-06-17T11:34:17Z
dc.date.issued2022-05-04
dc.identifier.issn1538-7755 (Electronic) 1055-9965 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140265
dc.description.abstractEnBACKGROUND: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non-Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes. METHODS: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell-mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n = 1,914), follicular lymphoma (n = 1,733), and marginal zone lymphoma (MZL; n = 407), using unconditional logistic regression. RESULTS: We demonstrated a positive association of DLBCL PRS with DLBCL risk [T2 vs. T1: OR = 1.24; 95% confidence interval (CI), 1.08-1.43; T3 vs. T1: OR = 1.81; 95% CI, 1.59-2.07; P-trend (Ptrend) < 0.0001]. DLBCL risk also increased with increasing PRS tertile among those with an autoimmune condition, being highest for those with a B-cell-mediated autoimmune condition and a T3 PRS [OR = 6.46 vs. no autoimmune condition and a T1 PRS, Ptrend < 0.0001, P-interaction (Pinteraction) = 0.49]. Follicular lymphoma and MZL risk demonstrated no evidence of joint associations or significant Pinteraction. CONCLUSIONS: Our results suggest that PRS constructed from currently known subtype-specific loci may not necessarily capture biological pathways shared with autoimmune conditions. IMPACT: Targeted genetic (PRS) screening among population subsets with autoimmune conditions may offer opportunities for identifying those at highest risk for (and early detection from) DLBCL.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.title.enB-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS
dc.typeArticle de revueen_US
dc.identifier.doi10.1158/1055-9965.Epi-21-0875en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35244686en_US
bordeaux.journalCancer Epidemiology, Biomarkers and Preventionen_US
bordeaux.page1103-1110en_US
bordeaux.volume31en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDEuropean Commissionen_US
bordeaux.identifier.funderIDEuropean Regional Development Funden_US
bordeaux.identifier.funderIDNational Cancer Instituteen_US
hal.identifierhal-03697957
hal.version2
hal.date.transferred2022-06-17T22:22:15Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Cancer%20Epidemiology,%20Biomarkers%20and%20Prevention&amp;rft.date=2022-05-04&amp;rft.volume=31&amp;rft.issue=5&amp;rft.spage=1103-1110&amp;rft.epage=1103-1110&amp;rft.eissn=1538-7755%20(Electronic)%201055-9965%20(Linking)&amp;rft.issn=1538-7755%20(Electronic)%201055-9965%20(Linking)&amp;rft.au=WANG,%20Sophia%20S.&amp;VAJDIC,%20Claire%20M.&amp;LINET,%20Martha%20S.&amp;SLAGER,%20Susan%20L.&amp;VOUTSINAS,%20Jenna&amp;rft.genre=article


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