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Prevalence of human leukocyte antigen HLA-B*57:01 in individuals with HIV in West and Central Africa
dc.rights.license | open | en_US |
dc.contributor.author | KOLOU, Malewe | |
dc.contributor.author | PODA, Armel | |
dc.contributor.author | DIALLO, Zelica | |
dc.contributor.author | KONOU, Esther | |
dc.contributor.author | DOKPOMIWA, Tatiana | |
dc.contributor.author | ZOUNGRANA, Jacques | |
dc.contributor.author | SALOU, Mounerou | |
dc.contributor.author | MBA-TCHOUNGA, Lionèle | |
dc.contributor.author | BIGOT, André | |
dc.contributor.author | OUEDRAOGO, Abdoul-Salam | |
dc.contributor.author | BOUYOUT-AKOUTET, Marielle | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | EKOUEVI, Didier Koumavi | |
dc.contributor.author | EHOLIE, Serge Paul | |
dc.date.accessioned | 2022-06-16T13:59:03Z | |
dc.date.available | 2022-06-16T13:59:03Z | |
dc.date.issued | 2021-07-22 | |
dc.identifier.issn | 1471-2172 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140246 | |
dc.description.abstractEn | Background: The presence of the human leukocyte antigen HLA-B*57:01 is associated with the development of a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*57:01 prevalence in individuals with HIV-1 in Africa. This study aimed to estimate HLA-B*57:01 prevalence in individuals with HIV-1 in West and Central Africa. Methods: A cross-sectional study was conducted in four countries in West and central Africa (Burkina-Faso, Côte d'Ivoire, Gabon, and Togo) from January 2016 to February 2020 to determine the status of HLA-B*57:01 in adults with HIV-1. The presence of HLA-B*57:01 was determined by using Single Specific Primer-Polymerase Chain Reaction (SSP-PCR) in blood samples. Prevalence rates were stratified based on country. Results: A total of 4016 (69.8% women) individuals with HIV were enrolled. Their median age was 45, and the interquartile range was 38-52. We included 500 (12.4%) patients in Burkina-Faso, 1453 (36.2%) in Côte d'Ivoire, 951 (23.7%) in Gabon, and 1112 (27.7%) in Togo. The overall HLA-B*57:01 prevalence was 0.1% [95% CI: 0.0-0.2%]. The prevalence of HLA-B*57:01 was similar according to the four countries. Only one case was reported in each country except Togo, with no cases. Conclusions: HLA-B*57:01 prevalence is low in individuals with HIV in West and central Africa, and there is no difference among countries. This study does not confirm the utility of HLA-B*57:01 allele testing for abacavir use in this region. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.en | Abacavir | |
dc.subject.en | And Central Africa | |
dc.subject.en | Antiretroviral | |
dc.subject.en | HIV infection | |
dc.subject.en | HLA-B*57:01 | |
dc.subject.en | Prevalence | |
dc.subject.en | West | |
dc.title.en | Prevalence of human leukocyte antigen HLA-B*57:01 in individuals with HIV in West and Central Africa | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1186/s12865-021-00427-7 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 34294032 | en_US |
bordeaux.journal | BMC Immunology | en_US |
bordeaux.page | 48 | en_US |
bordeaux.volume | 22 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 1 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | MORPH3Eus | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.export | false | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMC%20Immunology&rft.date=2021-07-22&rft.volume=22&rft.issue=1&rft.spage=48&rft.epage=48&rft.eissn=1471-2172&rft.issn=1471-2172&rft.au=KOLOU,%20Malewe&PODA,%20Armel&DIALLO,%20Zelica&KONOU,%20Esther&DOKPOMIWA,%20Tatiana&rft.genre=article |