Sex-specific Genome Wide Association Study Of Early-onset Ischemic Stroke
dc.rights.license | open | en_US |
dc.contributor.author | TOMPPO, Liisa | |
dc.contributor.author | RANNIKMAE, Kristiina | |
dc.contributor.author | STANNE, Tara M. | |
dc.contributor.author | PUTAALA, Jukka | |
dc.contributor.author | STRBIAN, Daniel | |
dc.contributor.author | JERN, Christina | |
dc.contributor.author | DE LEEUW, Frank Erik | |
dc.contributor.author | CADENAS, Israel Fernandez | |
dc.contributor.author | SLOWIK, Agnieszka M. | |
dc.contributor.author | BONCORAGLIO, Giorgio | |
dc.contributor.author | LINDGREN, Arne | |
dc.contributor.author | CONDE, Jordi J. | |
dc.contributor.author | SCHMIDT, Reinhold | |
dc.contributor.author | SHARMA, Pankaj | |
dc.contributor.author | LEMMENS, Robin | |
dc.contributor.author | MELANDER, Olle | |
dc.contributor.author | ROTHWELL, Peter | |
dc.contributor.author | LEVI, Christopher | |
dc.contributor.author | SUDLOW, Catherine | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DEBETTE, Stephanie | |
dc.contributor.author | METSO, Tiina | |
dc.contributor.author | PARE, Guillaume | |
dc.contributor.author | MARKUS, Hugh | |
dc.contributor.author | SALEHEEN, Danish | |
dc.contributor.author | DANESH, John | |
dc.contributor.author | ZAND, Ramin | |
dc.contributor.author | WORRALL, Bradford B. | |
dc.contributor.author | MESCHIA, James F. | |
dc.contributor.author | RUNDEK, Tatjana | |
dc.contributor.author | WOO, Daniel | |
dc.contributor.author | LEE, Jin Moo | |
dc.contributor.author | IRVIN, Marguerite R. | |
dc.contributor.author | MCDONOUGH, Caitrin W. | |
dc.contributor.author | REXRODE, Kathryn M. | |
dc.contributor.author | WASSERTHEIL-SMOLLER, Sylvia W. | |
dc.contributor.author | ROSAND, Jonathan | |
dc.contributor.author | GIEGER, Christian | |
dc.contributor.author | MULLER-NURASYID, Martina | |
dc.contributor.author | SALOMAA, Veikko V. | |
dc.contributor.author | KAMATANI, Yoichiro | |
dc.contributor.author | WALTERS, Robin | |
dc.contributor.author | CHEN, Zhengming | |
dc.contributor.author | DICHGANS, Martin | |
dc.contributor.author | MALIK, Rainer | |
dc.contributor.author | GAYNOR, Brady | |
dc.contributor.author | COLE, John | |
dc.contributor.author | XU, Huichun | |
dc.contributor.author | MITCHELL, Braxton D. | |
dc.contributor.author | KITTNER, Steven J. | |
dc.contributor.author | EARLY-ONSET STROKE, Consortium | |
dc.date.accessioned | 2022-06-15T07:48:36Z | |
dc.date.available | 2022-06-15T07:48:36Z | |
dc.date.issued | 2022-02 | |
dc.identifier.issn | 0039-2499 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140220 | |
dc.description.abstractEn | Introduction: Genetic studies of early-onset disease have been an effective strategy to identify novel pathways and drug targets generalizable also to later-onset disease. Few studies have investigated the sex-specific genetic associations with early-onset ischemic stroke even though several features of ischemic stroke differ between males and females. We hypothesized that stratifying the GWAS by sex would reveal novel stroke loci. Methods: We performed a transethnic ischemic stroke GWAS of 3,056 female cases and 4,462 male cases < 60 years-old and 16,192 and 16,048 sex-matched controls, respectively, from the Early Onset Stroke Genetics Consortium. Results: We identified a significant association in women with a locus in close proximity to TMX1, a transmembrane platelet protein that inhibits platelet function. Additionally, we identified 2 other suggestive (P < 5 x 10-6) loci in females (see Table), i.e., at APOH, which encodes beta2-glycoprotein I, an established GWAS locus for lipoprotein(a), and LRFN2 which has been previously reported to associate with obesity-related measures and type II diabetes. We observed suggestive evidence for association in males with MMP3/MMP12, a known stroke susceptibility locus. Conclusions: Despite a very modest sample size, sex-specific analyses identified suggestive associations at biologically important novel loci in females and a known stroke locus in males. Further studies of sex-specific associations in both early- and later-onset ischemic stroke are needed. | |
dc.language.iso | EN | en_US |
dc.subject.en | Gender differences | |
dc.subject.en | Ischemic stroke | |
dc.subject.en | Genome-wide association studies (GWAS) | |
dc.title.en | Sex-specific Genome Wide Association Study Of Early-onset Ischemic Stroke | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1161/str.53.suppl_1.154 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
bordeaux.journal | Stroke | en_US |
bordeaux.volume | 53 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | Suppl_1 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | ELEANOR_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-03696351 | |
hal.export | false | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Stroke&rft.date=2022-02&rft.volume=53&rft.issue=Suppl_1&rft.eissn=0039-2499&rft.issn=0039-2499&rft.au=TOMPPO,%20Liisa&RANNIKMAE,%20Kristiina&STANNE,%20Tara%20M.&PUTAALA,%20Jukka&STRBIAN,%20Daniel&rft.genre=article |
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