Effect of polystyrene nanoplastics and their degraded forms on stem cell fate
| dc.rights.license | open | en_US |
| dc.contributor.author | IM, Gwang-Bum | |
| dc.contributor.author | KIM, Young Geon | |
| hal.structure.identifier | Centre de Recherche Paul Pascal [CRPP] | |
| dc.contributor.author | JO, In-Seong | |
| dc.contributor.author | YOO, Tae Yong | |
| dc.contributor.author | KIM, Sung-Won | |
| dc.contributor.author | PARK, Hyun Su | |
| dc.contributor.author | HYEON, Taeghwan | |
| dc.contributor.author | YI, Gi-Ra | |
| dc.contributor.author | BHANG, Suk Ho | |
| dc.date.accessioned | 2022-06-09T16:03:33Z | |
| dc.date.available | 2022-06-09T16:03:33Z | |
| dc.date.issued | 2022 | |
| dc.identifier.issn | 3043894 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140172 | |
| dc.description.abstractEn | Several studies have examined the effects of micro- and nanoplastics on microbes, cells, and the environment. However, only a few studies have examined their effects—especially, those of their reduced cohesiveness—on cell viability and physiology. We synthesized surfactant-free amine-functionalized polystyrene (PS) nanoparticles (NPs) and PS-NPs with decreased crosslinking density (DPS-NPs) without changing other factors, such as size, shape, and zeta potential and examined their effects on cell viability and physiology. PS- and DPS-NPs exhibited reactive oxygen species (ROS) scavenging activity by upregulating GPX3 expression and downregulating HSP70 (ROS-related gene) and XBP1 (endoplasmic reticulum stress-related gene) expression in human bone marrow-derived mesenchymal stem cells (hBM-MSCs). Additionally, they led to upregulation of MFN2 (mitochondrial fusion related gene) expression and downregulation of FIS1 (mitochondrial fission related gene) expression, indicating enhanced mitochondrial fusion in hBM-MSCs. Cell-cycle analysis revealed that PS- and DPS-NPs increased the proportion of cells in the S phase, indicating that they promoted cell proliferation and, specifically, the adipogenic differentiation of hBM-MSCs. However, the cytotoxicity of DPS-NPs against hBM-MSCs was higher than that of PS-NPs after long-term treatment under adipogenic conditions. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Adipogenic differentiation | |
| dc.subject.en | Mesenchymal stem cells | |
| dc.subject.en | Nanoplastics | |
| dc.subject.en | Polystyrene | |
| dc.subject.en | Reactive oxygen species scavenging | |
| dc.title.en | Effect of polystyrene nanoplastics and their degraded forms on stem cell fate | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.jhazmat.2022.128411 | en_US |
| dc.subject.hal | Chimie/Matériaux | en_US |
| bordeaux.journal | Journal of Hazardous Materials | en_US |
| bordeaux.page | 128411 | en_US |
| bordeaux.volume | 430 | en_US |
| bordeaux.hal.laboratories | Centre de Recherche Paul Pascal (CRPP) - UMR 5031 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03692493 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-06-09T16:03:35Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Hazardous%20Materials&rft.date=2022&rft.volume=430&rft.spage=128411&rft.epage=128411&rft.eissn=3043894&rft.issn=3043894&rft.au=IM,%20Gwang-Bum&KIM,%20Young%20Geon&JO,%20In-Seong&YOO,%20Tae%20Yong&KIM,%20Sung-Won&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||